Results 181 to 190 of about 46,055 (312)

Differential Impact of Pneumococcal Conjugate Vaccines on Hospitalized <i>Versus</i> Outpatient Community-Acquired Alveolar Pneumonia in Children Younger Than 5 Years Suggests Differences in Pathogenesis. [PDF]

Open Forum Infect Dis
van der Beek BA, Greenberg D, Hazan G, Dagan R.   +3 more
europepmc   +1 more source

Impact of the Serogroup A Meningococcal Conjugate Vaccine, MenAfriVac, on Carriage and Herd Immunity [PDF]

, 2012
Paul A. Kristiansen, Fabien Diomandé, Absatou Ky Ba, Idrissa Sanou, Abdoul–Salam Ouédraogo, Rasmata Ouédraogo, Lassana Sangaré, Denis Kandolo, Flavien Aké, Inger Marie Saga, Thomas A. Clark, Lara Misegades, Stacey W. Martin, Jennifer D. Thomas, S Tiendrébéogo, M. Hassan-King, Mamoudou Harouna Djingarey, Nancy E. Messonnier, Marie‐Pierre Préziosi, F. Marc LaForce, Dominique A. Caugant   +20 more
openalex   +1 more source

Non‐Targeting shRNA‐Encoded Plasmid DNA Enhances Protective Immunity Through RIDD‐RIG‐I Signaling Pathway in the Zika Virus Animal Model

Advanced Science, EarlyView.
We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang, Hung‐Chun Liao, Po Peng, Wan‐Ling Wu, Kit Man Chai, Mei‐Yu Chen, Guann‐Yi Yu, Tsung‐Hsien Chuang, Hsin‐Wei Chen, Chuang‐Rung Chang, Shih‐Jen Liu   +10 more
wiley   +1 more source

Serotype 3 invasive pneumococcal disease in Tuscany across the eras of conjugate vaccines (2005-2024) and anthropic-driven respiratory virus fluctuations. [PDF]

Hum Vaccin Immunother
Lodi L, Catamerò F, Sarli WM, Moriondo M, Nieddu F, Ferraro E, Citera F, Astorino V, Giovannini M, Voarino M, Pelosi C, Quaranta F, Lippi F, Canessa C, Ricci S, Azzari C.   +15 more
europepmc   +1 more source

Validity of Enzyme-Linked Immunosorbent Assay (ELISA) as a correlate of protection of meningococcal C conjugated vaccine in adolescents with HIV infection

, 2020
Bertolini Daniela Vinhas, Costa Luciana Scarlazzari, de Castro Bruno Stuart, Pernichelli Tadeu, van der Heijden Inneke Marie, Costa Silvia Figueiredo, Sato Helena Keiko, de Sousa Marques Heloisa Helena   +7 more
openalex   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

A Cost-Effectiveness Analysis of the Switch to 20-Valent Pneumococcal Conjugate Vaccine from Lower-Valent Pneumococcal Conjugate Vaccines in the French Pediatric Population. [PDF]

Infect Dis Ther
Fiévez S, Ta A, Bellier L, Blanc E, El Khoury JY, Beillat M, Sabra A, Sivignon M, Ilic A, Perdrizet J.   +9 more
europepmc   +1 more source

Potential impact of introducing the pneumococcal conjugate vaccine into national immunisation programmes: an economic-epidemiological analysis using data from India [PDF]

, 2018
Itamar Megiddo, Eili Klein, Ramanan Laxminarayan   +2 more
openalex   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Development of invasive non-typhoidal Salmonella conjugate vaccines and their evaluation in a trivalent formulation with typhoid conjugate vaccine. [PDF]

Vaccine
An SJ, Yang JS, Chae MH, Woo JS, Kang YE, Ganapathy R, Pansuriya RK, Choi JA, Yoon YK, Lee E, Lee SB, Pandey G, Lee JW, Lee JS, Bae SH, Kweon SW, Kim SJ, Seon SH, Kim JH, Song M.   +19 more
europepmc   +1 more source