Results 281 to 290 of about 55,913 (304)

Early immunization with conjugate vaccines

Vaccine, 1998
Conjugate vaccines have been used during the neonatal period or in early infancy in order to test their safety and immunologic behaviour. Adverse events even in neonates and premature babies have been mild and spontaneously resolving. Anticapsular antibody concentrations after first doses of Hib conjugates in early infancy are generally low, but ...
Helena Käyhty, Juhani Eskola
openaire   +3 more sources

Polysaccharide Conjugate Typhoid Vaccine

New England Journal of Medicine, 2001
There is a growing appreciation of the huge health threat posed by increasingly resistant infectious diseases, especially in tropical areas of the developing world.
Richard L. Guerrant, Margaret Kosek
openaire   +3 more sources

Pneumococcal Conjugate Vaccines

1995
The development of multivalent pneumococcal vaccines for the prevention of both systemic and noninvasive pneumococcal diseases in infants, older adults, and immunecompromised individuals has gained increasing importance over the last decade. The rising cost of medical care has renewed interest in prevention instead of cure for a disease and in many ...
openaire   +3 more sources

The pneumococcal protein conjugate vaccines

The Journal of Pediatrics, 2000
to develop the first licensed pneumococcal vaccine, consisting of 14 purified capsular polysaccharide antigens representing the most prevalent disease-associated serotypes. Coverage was improved by the addition of 9 more purified polysaccharide antigens, resulting in the currently licensed 23valent pneumococcal capsular polysaccharide vaccine.
Timothy R. Peters, Kathryn M. Edwards
openaire   +3 more sources

PolysaccharicbConjugate Vaccines

2003
It was recognized early this century that small molecules, called haptens, can be made immunogenic after conjugation to carrier proteins (1), This principle was thereafter applied successfully to improve the rmmunogenicity of (poly)saccharides (2, 3). We now know that the carrier proteins ensure the involvement of T-helper lymphocytes in the activation
Odo de Weers, Peter Hoogerhout, Jan Poolman, Carla C. A. M. Peeters, Michel Beurret, Patrick R. Lagerman, Lukas A. Oomen   +6 more
openaire   +3 more sources

Conjugate vaccines: practice and theory

Springer Seminars in Immunopathology, 1993
Conjugate vaccines have already had a major impact on vaccination of infants against H. influenzae type b. The impact of conjugate vaccines will continue to grow as we apply this technology to other important diseases. The design of these vaccines will become more efficient and rational as we continue to understand the various facets and immunological ...
openaire   +3 more sources

Immunogenicity of pneumococcal conjugate vaccines

The Pediatric Infectious Disease Journal, 2000
Prevention of pneumococcal infections is a public health priority because of the high impact of the disease and because of the increasing problems due to antimicrobial resistance. Traditional vaccines, consisting of purified capsular polysaccharides (PSs) of Streptococcus pneumoniae, are not immunogenic in young children.
openaire   +3 more sources

Conjugate pneumococcal vaccines: an overview

Medical Journal of Australia, 2000
A seven-valent conjugate pneumococcal vaccine has been shown to have dramatic efficacy against invasive pneumococcal disease and lesser efficacy against otitis media and pneumonia. This vaccine was licensed for use in infants in the United States in February 2000 and is recommended there for routine use in infants and catch-up vaccination in high-risk ...
openaire   +3 more sources

Meningococcal tetravalent conjugate vaccine

Expert Opinion on Biological Therapy, 2008
Neisseria meningitidis is a leading cause of meningitis and sepsis worldwide. Since 1981, a tetravalent meningococcal polysaccharide vaccine has been available in the US but it has been limited to high-risk patients and outbreak settings. In 2005, a tetravalent polysaccharide meningococcal conjugate vaccine (MCV4) was licensed for routine use in the US.
openaire   +3 more sources

Pneumococcal conjugate vaccines

The Pediatric Infectious Disease Journal, 1999
Merja Anttila, Juhani Eskola
openaire   +6 more sources