Results 141 to 150 of about 91,670 (264)

Phenotypic and Genetic Characteristics of <i>bla</i>_IMP-6-Harboring <i>Enterobacterales</i> Isolates Lacking <i>bla</i>_CTX-M-2 in Japan. [PDF]

Int J Mol Sci
Yamaguchi K, Nakano R, Nakano A, Kishi R, Saito K, Watanabe M, Suzuki Y, Sakata R, Ogawa M, Yano H.   +9 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Mobile Genetic Elements as Central Drivers of Antimicrobial Resistance: Molecular Mechanisms, Evolutionary Ecology, One Health Implications and Control Strategies. [PDF]

Antibiotics (Basel)
Hossain H, Ali MH, Ahmad T, Sayeed SSB, Sakib MAN, Brishty KA, Saleh MSJ, Hosen MM, Ahmed S, Ahmed S, Chowdhury MSR, Rahman MM.   +11 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The flexible cotransfer of plasmids drives the dissemination of tet(X4) in swine Escherichia coli. [PDF]

Vet Res
Hao Z, Zhang C, Cui J, Xing S, Wei Z, Wu H, Liu J, Ma X, Fang Z, Yuan L.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Adaptations of <i>E. coli</i> SM10λpir (pUCP24T) Under Constant Sub-MIC Gentamicin Treatment. [PDF]

Can J Infect Dis Med Microbiol
He Y, Xiang G, Zhong G, Zeng J, Chen C, Huang B.   +5 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

<i>Planococcus dechangensis</i> NEAU-ST10-9^T Promotes Maize Seedling Root Development: Evidence from Effective Fluorescence Tracking. [PDF]

Microorganisms
Zhou Q, Huang Z, Li H, Xiong J, Chen M, Liu Y, Liu W, Yao Y, Gonzalez R, Li Y, Shi A, Lu F.   +11 more
europepmc   +1 more source