Results 51 to 60 of about 72,089 (292)

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

A Review of Ocular Surface Impression Cytology Along with the Recommended Methodology

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Impression cytology (IC) using specific filter paper is a non-invasive method to study ocular surface diseases. This method has been continuously under modification from its origin. The yield of cells depends on the properties of the filter paper and the
Rekha Chotaliya, Neeta Mishra, Archana Buch, Neelam Prasad   +3 more
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Hyperglycemia causes differential change in macrophage population in the lacrimal gland, conjunctiva and cornea

Frontiers in Immunology
BackgroundDue to its location, the ocular surface is exposed to environmental microbes. Innate immune cells including macrophages are first line defense against infections.
Saleh Alfuraih, Saleh Alfuraih, Saleh Alfuraih, Amy Tran, Lois Kim, Rais Ansari, Ajay Sharma   +6 more
doaj   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

ueber Frühjahrskatarrh der Conjunctiva

, 1872
UEBER FRÜHJAHRSKATARRH DER CONJUNCTIVA Franciscus Cornelius Donders Library (-) ueber Frühjahrskatarrh der Conjunctiva (-
Brockhaus, Carl
core   +1 more source

Diversity of Bacteria at Healthy Human Conjunctiva [PDF]

, 2011
Article on the diversity of bacteria at healthy human ...
Darlene Miller, Antonopoulos, Dionysios A., Shestopalov, Valery I., Miller, Darlene, Gao, Xiang, Dong, Qunfeng, Brandon Bates, Antonopoulos, Dionysios A, Aaron Garoutte, Brulc, Jennifer M., Qunfeng Dong, Brulc, Jennifer M, Valery I. Shestopalov, Dionysios A. Antonopoulos, Revanna, Kashi V., Shestopalov, Valery I, Revanna, Kashi V, Kashi V. Revanna, Bates, Brandon, Garoutte, Aaron, Xiang Gao, Jennifer M. Brulc, Iovieno, Alfonso, Alfonso Iovieno, Vladlen Z. Slepak, Slepak, Vladlen Z, Slepak, Vladlen Z.   +26 more
core   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Electrophysiological abnormalities associated with extensive myelinated retinal nerve fibers

Indian Journal of Ophthalmology, 2012
An observational case report of electrophysiological abnormalities in a patient with anisomyopic amblyopia as a result of unilateral extensive myelinated retinal nerve fibers (MNFs) is illustrated.
Su Ann Tay, Srinivasan Sanjay
doaj   +1 more source

Ocular Surface Inflammatory Disorders (OSID): A Collective of Systemic Etiologies Which Cause or Amplify Dry Eye Syndrome

Frontiers in Medicine, 2022
The ocular surface inflammatory disorders (OSID) are caused by systemic disorders that conduct a persistent inflammatory reaction in the ocular adnexal connective tissues, such as the conjunctiva, lacrimal gland (LG) and meibomian glands (MGs), which ...
Matias Soifer, Matias Soifer, Nadim S. Azar, Nadim S. Azar, Hazem M. Mousa, Hazem M. Mousa, Victor L. Perez, Victor L. Perez   +7 more
doaj   +1 more source