Results 51 to 60 of about 337 (251)

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

ConKeD: multiview contrastive descriptor learning for keypoint-based retinal image registration

Medical & Biological Engineering & Computing
Abstract Retinal image registration is of utmost importance due to its wide applications in medical practice. In this context, we propose ConKeD, a novel deep learning approach to learn descriptors for retinal image registration.
David Rivas-Villar, Álvaro S. Hervella, José Rouco, Jorge Novo   +3 more
openaire   +4 more sources

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, EarlyView.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

A study on the conks originated from Sivas

, 2001
Sosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim DalıÖZET Cönkler, yüzyıllar önce yaşamış olan Türk halk şairlerinin şiirlerinin bulunduğu edebî kaynaklardır. Bizlere geçmiş hakkında bilgiler sunduğu için kültürel açıdan önemi büyüktür. Biz de
Öztosun, Sevgi
core  

8 AĞUSTOS 1915 TARİHİNDE CONK BAYIRI'NDA TÜRKLER VE YENİ ZELANDALILARIN MÜCADELESİ

Askeri Tarih Araştırmaları Dergisi, 2021
İngiliz hükümeti Çanakkale Cephesini İstanbul’u hedefleyerek açmıştı. Deniz yolu başarı getirmeyince, karaya çıkarma ile yaptıkları ataklarda, en ilerledikleri pozisyon Conk Bayırı’nda 8 Ağustos’ta geldikleri mevzi olmuştu. İngiliz Ordusu içindeki Yeni Zelanda birlikleri 25.
openaire   +2 more sources

Mesoporous Catalytic‐Adsorptive Nanoregulator Orchestrates Biofilm eDNA/LPS Disassembly and TLR9/TLR4 Immune Reprogramming to Resolve Diabetic Foot Infections

Advanced Science, EarlyView.
Chronic diabetic wounds are hindered by a “dual trap” of biofilm resistance and hyperinflammation. A mesoporous catalytic‐adsorptive nano‐regulator is developed to dismantle this barrier through simultaneous eDNA degradation and LPS sequestration. By silencing TLR4/9‐mediated signaling, the platform clears resilient pathogens and reprograms the immune ...
Junfeng Song, Yang Song, Xirui Huang, Xingjin Li, Lifei Gao, Yixiang Wang, Tianbao Zhu, Xiaomin Li, Shuai Wang, Tiancong Zhao, Dongyuan Zhao   +10 more
wiley   +1 more source

conks

, 1956
conkNoun. Knee-length leather boots.L.Harris January 1956Not usedNot usedWithdrawnChecked by Jordyn Hughes on Tue 05 Jul ...

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Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

conks

, 1959
conkKnee-length leather or rubber boots.DNE-cit G.M.Story June 1956Not usedNot usedWithdrawnChecked by Jordyn Hughes on Tue 05 Jul 2016, stamped but not ...

core