Results 51 to 60 of about 375 (237)

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

A study on weld Library Ziyabey conks (6771,6774,6776,6777 the number of conks)

, 2010
Bu çalışmanın konusu Sivas Ziya Bey Kütüphanesi'nden alınan 6771, 6774 numaralı cönkler ve 6776, 6777 numaralı mecmuaların okunması incelenmesi ve değerlendirilmesidir.Bu amaç doğrultusunda öncelikle, alınan yazma nüshalar transkriptli metin olarak ...
Güzel, Cavit
core  

8 AĞUSTOS 1915 TARİHİNDE CONK BAYIRI'NDA TÜRKLER VE YENİ ZELANDALILARIN MÜCADELESİ

Askeri Tarih Araştırmaları Dergisi, 2021
İngiliz hükümeti Çanakkale Cephesini İstanbul’u hedefleyerek açmıştı. Deniz yolu başarı getirmeyince, karaya çıkarma ile yaptıkları ataklarda, en ilerledikleri pozisyon Conk Bayırı’nda 8 Ağustos’ta geldikleri mevzi olmuştu. İngiliz Ordusu içindeki Yeni Zelanda birlikleri 25.
openaire   +2 more sources

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

A study on the conks originated from Sivas

, 2001
Sosyal Bilimler Enstitüsü, Türk Dili ve Edebiyatı Ana Bilim DalıÖZET Cönkler, yüzyıllar önce yaşamış olan Türk halk şairlerinin şiirlerinin bulunduğu edebî kaynaklardır. Bizlere geçmiş hakkında bilgiler sunduğu için kültürel açıdan önemi büyüktür. Biz de
Öztosun, Sevgi
core   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

ConKeD: multiview contrastive descriptor learning for keypoint-based retinal image registration

Medical & Biological Engineering & Computing
Abstract Retinal image registration is of utmost importance due to its wide applications in medical practice. In this context, we propose ConKeD, a novel deep learning approach to learn descriptors for retinal image registration.
David Rivas-Villar, Álvaro S. Hervella, José Rouco, Jorge Novo   +3 more
openaire   +6 more sources

Osseoperceptive EMG Feedback Improves Grasp Force Control in Myoelectric Prosthetic Hands

Advanced Science, EarlyView.
Osseoperception is explored as a non‐invasive pathway for delivering sensory feedback in myoelectric prosthetic control. By encoding the user's electromyographic (EMG) signal through bone‐conducted stimulation, this approach enables predictive grasp force regulation.
Cristian Felipe Blanco‐Diaz, Strahinja Dosen, Leonardo Cappello   +2 more
wiley   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source