Results 91 to 100 of about 822,818 (296)

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

open access: yesAdvanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins   +3 more
wiley   +1 more source

In Vivo Skin 3‐D Surface Reconstruction and Wrinkle Depth Estimation Using Handheld High Resolution Tactile Sensing

open access: yesAdvanced Healthcare Materials, EarlyView.
A compact handheld GelSight probe reconstructs in vivo 3‐D skin topography with micron‐level precision using a custom elastic gel and a learning‐based surface normal to height map pipeline. The device quantifies wrinkle depth across various body locations and detects changes in wrinkle depth following moisturizer application.
Akhil Padmanabha   +12 more
wiley   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

open access: yesAdvanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach   +7 more
wiley   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

open access: yesAdvanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy