Results 91 to 100 of about 87,170,517 (282)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Needs to connect to urban nature in female university students from Southern Germany: a mixed methods concept mapping study

Frontiers in Public Health
Mental health problems are a major global health concern today. Psychological well-being, such as mental health, can be improved through nature connectedness. Nature connectedness is a co-benefit of planetary health. However, access to nature, along with
Dorothea M. I. Schönbach, Dorothea M. I. Schönbach, Ximena Tiscareno-Osorno, Tadhg E. MacIntyre, Tadhg E. MacIntyre, Stephen Smith, Deirdre MacIntyre, Yolanda Demetriou   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

CHILDREN’S DIRECT AND INDIRECT EXPERIENCES WITH NATURE AND THEIR CONNECTEDNESS TO NATURE

PLANNING MALAYSIA, 2019
Direct experiences with nature during childhood plays an important role to influence children’s connectedness to nature (CTN) as a child now and later as an adult. However, today’s children obtain nature experiences mostly through indirect ways (e.g.
Nor Diyana Mustapa, Nor Zarifah Maliki, Nor Fadzila Aziz, Aswati Hamzah   +3 more
openaire   +2 more sources

Parental positive thinking and psychological flexibility in relation to children’s nature connectedness: the mediating role of family functioning

BMC Psychology
Background To strengthen children’s nature connectedness, this study explored the mechanisms linking parental positive thinking, parental psychological flexibility, and young children’s nature connectedness, with a focus on the mediating role of family ...
Lina Ma, Zhonglian Yan, Yuedi Yang, Haojie Yuan, Wei Xiao   +4 more
doaj   +1 more source

The overview effect and nature-relatedness

Frontiers in Virtual Reality
Climate scientists increasingly agree that human behavior significantly contributes to global warming and biodiversity decline. Recent research emphasizes the importance of human-nature connectedness as a reliable predictor of psychological wellbeing and
Niall McKeever, Annahita Nezami, Dimitrios Kourtis   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

What predicts well-being: connectedness to oneself, nature, others, or the transcendent?

Cogent Psychology
Well-being is essential for all people. Therefore, important factors influencing people’s well-being must be investigated. Well-being is multifaceted and defined as, for example, psychological, emotional, mental, physical, or social well-being.
Martina Rahe, Petra Jansen
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source