Results 121 to 130 of about 288,450 (309)
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Connective structure for principal gerbes [PDF]
arXiv, 2005 In this paper we generalize the notion of connective structure defined by Pierre Deligne to gerbes bounded by the automorphisms group of a principal bundle.
arxiv
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
Principal bundles on compact complex manifolds with trivial tangent bundle [PDF]
arXiv, 2011 Let $G$ be a connected complex Lie group and $\Gamma\subset G$ a cocompact lattice. Let $H$ be a complex Lie group. We prove that a holomorphic principal $H$-bundle $E_H$ over $G/\Gamma$ admits a holomorphic connection if and only if $E_H$ is invariant.
arxiv
Mapping Hsp104 interactions using cross‐linking mass spectrometry
FEBS Open Bio, EarlyView.This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal +3 more
wiley +1 more source
Дифференциальная геометрия многообразий фигур, 2018 Space П of centred m-planes is considered in the projective space . Principal fiber bundle is arised above it. Two-index structural forms of the principal fiber are included also into structure of basic forms.
O. Belova
doaj
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
On some flat connection associated with locally symmetric surface
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2014 For every two-dimensional manifold M with locally symmetric linear connection nabla, endowed also with nabla-parallel volume element, we construct a flat connection on some principal fibre bundle P(M,G).
Maria Robaszewska
doaj
Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis
FEBS Open Bio, EarlyView.Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu +6 more
wiley +1 more source
Quantum Principal Bundles [PDF]
arXiv, 1993 A noncommutative-geometric generalization of the theory of principal bundles is sketched. A differential calculus over corresponding quantum principal bundles is analysed. The formalism of connections is presented. In particular, operators of covariant derivative and horizontal projection are described and analysed. Quantum counterparts for the Bianchi
arxiv