Results 21 to 30 of about 1,425,624 (248)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Distance and the pattern of intra-European trade [PDF]

open access: yes, 1956
Given an undirected graph G = (V, E) and subset of terminals T ⊆ V, the element-connectivity κ ′ G (u, v) of two terminals u, v ∈ T is the maximum number of u-v paths that are pairwise disjoint in both edges and non-terminals V \ T (the paths need not be
A. Frank   +19 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Eccentric connectivity index [PDF]

open access: yes, 2010
The eccentric connectivity index $\xi^c$ is a novel distance--based molecular structure descriptor that was recently used for mathematical modeling of biological activities of diverse nature. It is defined as $\xi^c (G) = \sum_{v \in V (G)} deg (v) \cdot
Ilić, Aleksandar
core  

On the strengths of connectivity and robustness in general random intersection graphs [PDF]

open access: yes, 2014
Random intersection graphs have received much attention for nearly two decades, and currently have a wide range of applications ranging from key predistribution in wireless sensor networks to modeling social networks.
Gligor, Virgil, Yağan, Osman, Zhao, Jun
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

A concept of weighted connectivity on connected graphs [PDF]

open access: yes, 2009
The introduction of a {0,1}-valued game associated to a connected graph allows us to assign to each node a value of weighted connectivity to the different solutions that for the cooperative games are obtained by means of the semivalues.
Amer Ramon, Rafael   +1 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

To Be Connected, or Not to Be Connected [PDF]

open access: yesProceedings of the 2017 ACM on Conference on Information and Knowledge Management, 2017
In Proceedings of the 26th ACM conference on Information and Knowledge Management (CIKM 2017)
Natali Ruchansky   +4 more
openaire   +3 more sources

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