Results 141 to 150 of about 64,126 (335)

Experimental Parkinsonism induced by tetanus toxin injected into basal ganglia

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Local inhibitory circuits and long‐range inhibitory projections within the interconnected basal ganglia nuclei are critical for control of voluntary movement and pathophysiology of different extrapyramidal movement disorders.
Patrik Meglić, Petra Šoštarić, Davor Virag, Ana Knezović, Nikola Habek, Ornella Rossetto, Ivica Matak   +6 more
wiley   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Schizophrenia, neuroimaging and connectomics

NeuroImage, 2012
Schizophrenia is frequently characterized as a disorder of brain connectivity. Neuroimaging has played a central role in supporting this view, with nearly two decades of research providing abundant evidence of structural and functional connectivity abnormalities in the disorder.
Alex Fornito, Christos Pantelis, Andrew Zalesky, Edward T. Bullmore, Edward T. Bullmore   +4 more
openaire   +3 more sources

Developmental and epileptic or epileptic encephalopathy with spike–wave activation in sleep: From the ‘functional ablation’ model to a neurodevelopmental network perspective

Developmental Medicine &Child Neurology, EarlyView.
The pathophysiology of D/EE‐SWAS has traditionally been conceptualized as a cause–effect continuum wherein genetic and environmental factors influence brain morphology, subsequently inducing electrical abnormalities during sleep, resulting in cognitive impairment.
Luca Andreoli, Stefania Maria Bova, Pierangelo Veggiotti   +2 more
wiley   +1 more source

Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation

Neurobiology of Disease
The gut microbiota produces metabolites that enrich the host metabolome and play a part in host physiology, including brain functions. Yet the biological mediators of this gut-brain signal transduction remain largely unknown.
Hayatte-Dounia Mir, Qingning Yang, Elise Maximin, Quentin Montardy, Shuqin Ji, Qi Cheng, Xiaochun Shan, Liping Wang, Laurent Naudon, Sylvie Rabot, Lei Li   +10 more
doaj  

Functional connectome predicting individual gait function and its relationship with molecular architecture in Parkinson's disease

Neurobiology of Disease, 2023
Gait impairment is a common symptom of Parkinson's disease (PD), but its neural signature remains unclear due to the interindividual variability of gait performance.
Haoting Wu, Chenqing Wu, Jianmei Qin, Cheng Zhou, Sijia Tan, Xiaojie DuanMu, Xiaojun Guan, Xueqin Bai, Tao Guo, Jingjing Wu, Jingwen Chen, Jiaqi Wen, Zhengye Cao, Ting Gao, Luyan Gu, Peiyu Huang, Baorong Zhang, Xiaojun Xu, Minming Zhang   +18 more
doaj  

Statistical Connectomics

, 2014
Slides for talk I gave at Harvard University on February 2010.
openaire   +1 more source

Mechanisms of Connectome Development [PDF]

Trends in Cognitive Sciences, 2017
At the centenary of D'Arcy Thompson's seminal work 'On Growth and Form', pioneering the description of principles of morphological changes during development and evolution, recent experimental advances allow us to study change in anatomical brain networks. Here, we outline potential principles for connectome development. We will describe recent results
openaire   +4 more sources

The use of automated and AI‐driven algorithms for the detection of hippocampal sclerosis and focal cortical dysplasia

Epilepsia, EarlyView.
Abstract In drug‐resistant epilepsy, magnetic resonance imaging (MRI) plays a central role in detecting lesions as it offers unmatched spatial resolution and whole‐brain coverage. In addition, the last decade has witnessed continued developments in MRI‐based computer‐aided machine‐learning techniques for improved diagnosis and prognosis. In this review,
Andrea Bernasconi, Ravnoor S. Gill, Neda Bernasconi   +2 more
wiley   +1 more source

Neurobehavioral therapy in functional seizures: Investigation of mechanism of action with resting‐state functional magnetic resonance imaging

Epilepsia, EarlyView.
Abstract Objective Functional seizures (FS) often disrupt the key regions integral to cognitive processing and emotional regulation (anterior insula, anterior cingulate, and temporoparietal junction). We investigated the potential neurophysiologic mechanism of action (MOA) of neurobehavioral therapy (NBT) using resting‐state functional MRI seed‐based ...
Jerzy P. Szaflarski, W. Curt LaFrance Jr., Rodolphe Nenert, Jane B. Allendorfer, Stephen Correia, Tyler E. Gaston, Adam M. Goodman, Leslie E. Grayson, Noah Philip   +8 more
wiley   +1 more source