Results 21 to 30 of about 8,362 (210)
Connectomics and epilepsy [PDF]
Current Opinion in Neurology, 2013 Tremendous advances have occurred in recent years in elucidating basic mechanisms of epilepsy at the level of ion channels and neurotransmitters. Epilepsy, however, is ultimately a disease of functionally and/or structurally aberrant connections between neurons and groups of neurons at the systems level.
Jerome Engel +6 more
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Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Comparative connectomics—the study of neural circuits at synaptic resolution across species or the life span—promises to reveal how evolution modifies the nervous system to shape behavior and perception.
Yeon Jin Kim +5 more
semanticscholar +1 more source
Genetics of the connectome [PDF]
NeuroImage, 2013 Connectome genetics attempts to discover how genetic factors affect brain connectivity. Here we review a variety of genetic analysis methods--such as genome-wide association studies (GWAS), linkage and candidate gene studies--that have been fruitfully adapted to imaging data to implicate specific variants in the genome for brain-related traits. Studies
Tian Ge +6 more
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bioRxiv, 2023 Recent advances in connectomics research enable the acquisition of increasing amounts of data about the connectivity patterns of neurons. How can we use this wealth of data to efficiently derive and test hypotheses about the principles underlying these ...
Jan Boelts +8 more
semanticscholar +1 more source
A Genetic Model of the Connectome [PDF]
Neuron, 2020 The connectomes of organisms of the same species show remarkable architectural and often local wiring similarity, raising the question: where and how is neuronal connectivity encoded? Here, we start from the hypothesis that the genetic identity of neurons guides synapse and gap-junction formation and show that such genetically driven wiring predicts ...
Albert-László Barabási +3 more
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Expanding connectomics to the laminar level: A perspective
Network Neuroscience, 2023 Despite great progress in uncovering the complex connectivity patterns of the human brain over the last two decades, the field of connectomics still experiences a bias in its viewpoint of the cerebral cortex.
I. Shamir, Y. Assaf
semanticscholar +1 more source
Connectomics of Human Electrophysiology
NeuroImage, 2021 We present both a scientific overview and conceptual positions concerning the challenges and assets of electrophysiological measurements in the search for the nature and functions of the human connectome. We discuss how the field has been inspired by findings and approaches from functional magnetic resonance imaging (fMRI) and informed by a small ...
Sepideh Sadaghiani +2 more
openaire +5 more sources
Cartography and Connectomes [PDF]
Neuron, 2013 The past 25 years have seen great progress in parcellating the cerebral cortex into a mosaic of many distinct areas in mice, monkeys, and humans. Quantitative studies of interareal connectivity have revealed unexpectedly many pathways and a wide range of connection strengths in mouse and macaque cortex. In humans, advances in analyzing "structural" and
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Cancers, 2023 Simple Summary Diagnosing true progression (TP) versus radiation necrosis (RN) in brain metastases treated with stereotactic radiosurgery is a significant clinical challenge that can lead to delays of care or unnecessary neurosurgical procedures.
Yilin Cao +8 more
semanticscholar +1 more source
The FASEB Journal, 2013 Connectional maps of the brain may have value in developing models of both how the brain works and how it fails when subsets of neurons or synapses are missing or misconnected. Such maps might also provide detailed information about how brain circuits develop and age. I am eager to obtain such maps in neonatal animals because of a longstanding interest
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