Results 151 to 160 of about 296,728 (357)
MAP4K2 connects the Hippo pathway to autophagy in response to energy stress
, 2023 Gayoung Seo, Joshua Mckinley, Wenqi Wang
openalex +2 more sources
Naked cuticle is essential for Drosophila wing development beyond Wingless signaling
FEBS Open Bio, EarlyView.Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley +1 more source
Heart catheter cable and connector [PDF]
, 1972 Ultraminiature catheter cables that are stiff enough for intravenous insertion yet flexible at the tip, sterilizable, and economical are fabricated entirely from commercially available parts.
Cota, F. L. +2 more
core +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Improved solderless connector is easily disconnected [PDF]
, 1965 Compression type solderless connector is easily disconnected and reassembled and resists vibration. The connector, which uses a tapered split sleeve that is tightened by a nut into a mating bug, is used in place of standard solder lugs and to connect ...
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Continuity tester screens out faulty socket connections [PDF]
, 1964 A device, used before and after assembly, tests the continuity of an electrical circuit through each pin and socket of multiple connector sockets. Electrically insulated except at the contact area, a test probe is dimensioned to make contact only in ...
Golding, G.
core +1 more source
A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy
, 2017 Fereidoon Daryaee +6 more
openalex +2 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Percutaneous connector device [PDF]
, 1976 A device is reported for facilitating the passage of electrical signals from an external source through the skin of a patient to internal portions of the body such as muscles and nerves.
Parsons, W. E.
core +1 more source