Results 221 to 230 of about 25,696 (242)
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Biochimie, 2010
The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
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The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
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Expression of connexin 43 by atypical fibroxanthoma
Journal of Cutaneous Pathology, 2020AbstractIntroductionConnexins are transmembrane channel proteins that interconnect adjacent cells and allow the exchange of signaling molecules between cells and the extracellular milieu. They have been investigated in many tumors to obtain information about tumor nature, behavior, and prognosis.MethodsHerein, we present a study on the ...
Angel Fernandez‐Flores +3 more
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Connexin 43 in ischemic pre- and postconditioning
Heart Failure Reviews, 2007Connexin 43 (Cx43) is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium, but Cx43 is also localized at the inner membrane of cardiomyocyte mitochondria. In cardiomyocytes, Cx43 is involved in the formation of reactive oxygen species, which are central to the signal transduction cascade of ischemic ...
Rainer, Schulz +5 more
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Expression of connexin 43 in human testis
Histochemistry and Cell Biology, 1999In order to further characterize the Sertoli cell state of differentiation, we investigated the expression of connexin 43 (cx43) protein in the testis of adult men both with normal spermatogenesis and associated with spermatogenic impairment, since cx43 is first expressed during puberty.
K, Steger, F, Tetens, M, Bergmann
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Pulpal upregulation of connexin 43 during pulpitis
Clinical Oral Investigations, 2020Connexins are building blocks of membranous channels that form gap junctions and hemichannels. These channels are essential portals for information exchange and coordination during inflammation. Pathologic levels of these conduits may result in excessive inflammation and collateral destruction.
Wen Yi Lim +2 more
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Role of connexin 43 in cardiovascular diseases
European Journal of Pharmacology, 2015Gap junctions (GJs) channels provide the basis for intercellular communication in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone and endothelial function as well as metabolic interchange between the cells. They allow the transfer of small molecules and may enable slow calcium wave spreading, transfer
PECORARO, MICHELA +3 more
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Redistribution of connexin 43 during cell division
Cell Biology International, 2016AbstractGap junction channels, once clustered into gap junction plaques, allow communication of essential metabolites between cells. Gap junction plaques have been reported to be lost from the cell surface during cell division. The mechanism involved in this loss of gap junction plaques during mitosis is unclear, but we hypothesize that an ...
Oluseyi A, Vanderpuye +2 more
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Posttranscriptional regulation of connexin-43 expression
Archives of Biochemistry and Biophysics, 2012Posttranscriptional regulation of the biosynthesis of connexins, the building blocks of gap junctional channels, may occur by modulation of connexin mRNA stability and translation. To date, few RNA binding proteins and micro-RNAs (miRNAs) affecting connexin expression are known.
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Mature olfactory receptor neurons express connexin 43
The Journal of Comparative Neurology, 2000The expression of the gap junction subunit connexin 43 was studied in the olfactory epithelium of adult mice. In agreement with conclusions from previous immunohistochemical studies, we observed expression of mRNA encoding for connexin 43 in layers of the epithelium containing nuclei belonging to sustentacular cells.
C, Zhang, T E, Finger, D, Restrepo
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Endothelial Connexin 37, Connexin 40, and Connexin 43 Respond Uniquely to Substrate and Shear Stress
Endothelium, 2007Endothelial connexins have been linked to atherosclerosis and hypertension; however, little is know about their sensitivity to stimuli and individual functions. This study investigates the responses of endothelial connexin 37, connexin 40, and connexin 43 (Cx37, Cx40, and Cx43) to shear stress and substrate.
Tiffany L, Johnson, Robert M, Nerem
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