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Expression of connexin 43 in human testis [PDF]
In order to further characterize the Sertoli cell state of differentiation, we investigated the expression of connexin 43 (cx43) protein in the testis of adult men both with normal spermatogenesis and associated with spermatogenic impairment, since cx43 is first expressed during puberty.
Frank Tetens+2 more
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Expression of connexin 43 by atypical fibroxanthoma
Journal of Cutaneous Pathology, 2020AbstractIntroductionConnexins are transmembrane channel proteins that interconnect adjacent cells and allow the exchange of signaling molecules between cells and the extracellular milieu. They have been investigated in many tumors to obtain information about tumor nature, behavior, and prognosis.MethodsHerein, we present a study on the ...
Angel Fernandez‐Flores+3 more
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Role of connexin 43 in cardiovascular diseases
European Journal of Pharmacology, 2015Gap junctions (GJs) channels provide the basis for intercellular communication in the cardiovascular system for maintenance of the normal cardiac rhythm, regulation of vascular tone and endothelial function as well as metabolic interchange between the cells. They allow the transfer of small molecules and may enable slow calcium wave spreading, transfer
PECORARO, MICHELA+3 more
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Connexin 43 in ischemic pre- and postconditioning
Heart Failure Reviews, 2007Connexin 43 (Cx43) is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium, but Cx43 is also localized at the inner membrane of cardiomyocyte mitochondria. In cardiomyocytes, Cx43 is involved in the formation of reactive oxygen species, which are central to the signal transduction cascade of ischemic ...
Yukun Luo+5 more
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Characterization of connexin 30.3 and 43 in thymocytes
Immunology Letters, 2004During maturation, thymocytes interact directly and indirectly with different cell types of the thymic microenvironment. Such a cellular communication has been basically ascribed to soluble factors and surface receptors. However, little attention has been given to cellular communication mediated by gap junctions.
Marcia Urban-Maldonado+8 more
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Connexin 43 is localized with actin in tenocytes
Cell Motility, 2006AbstractVarieties of cell–matrix or cell–cell adhesions are associated with the actin cytoskeleton. However, for gap junctions, which are both channels and adhesions, there has been little evidence for such an association. The purpose of this study was to determine if connexin 43 (Cx43) associates with actin and to determine if this association is ...
Carol A. Otey+3 more
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Glomerular expression of connexin 40 and connexin 43 in rat experimental glomerulonephritis [PDF]
Gap junctional intercellular communication is thought to play an important role in the maintenance of cell differentiation and homeostasis. Gap junctions connect glomerular mesangial cells to each other. In this study, we examined the glomerular expression of connexins (Cxs) 40 and 43 at both the protein and transcript levels in anti-Thy1.1 ...
Shinichi Okada+9 more
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Expression of connexin 26 and connexin 43 is reduced in Hirschsprung's disease
Journal of Surgical Research, 2016Despite having an optimal pull-through operation, some children with Hirschsprung's disease (HSCR) continue to experience persistent bowel symptoms. Coordinated colonic electrical activity depends on intercellular communication between the enteric nerves, interstitial cells of Cajal (ICCs), smooth muscle cells, and fibroblast-like (platelet-derived ...
Anne Marie O'Donnell+6 more
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Biochimie, 2010
The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Dominique Segretain+4 more
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The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Dominique Segretain+4 more
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Remodeling of connexin 43 in the diabetic rat heart [PDF]
In the Streptozotocin-induced diabetic rat heart, a decrease in the conductivity and suppression of electrical cell-to-cell coupling were observed. To clarify this mechanism, the present study was performed to investigate alterations of the gap junction connexin 43 (Cx43) using immunoblotting, immunohistochemistry, electron-microscopic analyses.
Koichi Ogawa+3 more
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