Results 61 to 70 of about 38,372 (307)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
MULTIMODAL ANALYSIS ON SHOP SIGNS IN BANDA ACEH
English Education Journal: Jurnal Pengembangan Pendidikan dan Pengembangan Pengajaran Bahasa, 2020 This study is aimed at discovering the connotation and denotation that can be interpreted in shop signs found in Banda Aceh. Additionally, it also sought for the visuality, spatiality, and gestures that can be interpreted in shop sign found in Banda Aceh.
Yanti Zulita, Kismullah Abdul Muthalib
doaj
Framed field experiments with heterogeneous frame connotation [PDF]
, 2013 We study label framing effects in linear public goods games. By accounting for heterogeneous frame connotation, we can identify individual framing effects. We test for such effects in a field experiment on irrigation management in India. Using membership
Ansink, Erik +4 more
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2015 The article dwells on the emotional dominant of fear in the text of neo-gothic fiction. This text type is popular with the readership and viewed as a manifestation of the socalled "culture of fear" (F. Furedi).
Sergey Mihaylovich Pashkov
doaj +1 more source
Probing Power by Prompting: Harnessing Pre-trained Language Models for Power Connotation Framing
, 2023 When describing actions, subtle changes in word choice can evoke very different associations with the involved entities. For instance, a company ‘employing workers’ evokes a more positive connotation than the one ‘exploiting’ them. This concept is called
Khanehzar, S
core +1 more source
Thermodynamics’ Microscopic Connotations
, 2012 La termodinámica es la ciencia de la conversión de energía. Implica calor y otras formas de energía, siendo la mecánica la más importante. La energía potencial es la capacidad de hacer trabajo debido a la posición de algo. La energía cinética se debe al movimiento, dependiendo de la masa y la velocidad.
A. Plastino, E. M. F. Curado, M. Casas
openaire +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source