Results 251 to 260 of about 314,852 (352)

The Downfall of Health and Wellness as a Challenge to Humanity: Using Science Fiction to Highlight a Real-Life Crisis. [PDF]

Am J Lifestyle Med
Arena R.
europepmc   +1 more source

'What remains behind': Hellenism and Romanitas in Christian Egypt after the Arab conquest [PDF]

, 2009
Papaconstantinou, Arietta
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Design of CONQUEST, a novel, randomized, placebo-controlled, Phase 2b platform clinical trial to investigate new treatments for patients with early active systemic sclerosis with interstitial lung disease. [PDF]

J Scleroderma Relat Disord
Khanna D, Evnin LB, Assassi S, Benton WW, Gordon G, Maslova K, Steffgen J, Maher TM.   +7 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Three-dimensional reverse CART by rotation-overlap method: CLARP manoeuvre. [PDF]

AsiaIntervention
Leung C, Ho CB, Shing MC, Lee MK, Chun Chan AK.   +4 more
europepmc   +1 more source

Book Reviews [PDF]

, 1941

core   +1 more source

Interaction In Critical Systems : Conquests And Challenges

, 2007
Guimarães, Baranauskas M.C.C., E Martins   +2 more
openalex   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Patterns of care in the management of high-risk COPD in Australia (2015-2019): an observational study for the CONQUEST quality improvement program. [PDF]

Lancet Reg Health West Pac
Jenkins C, Dickens AP, Evans A, Le Cheng P, Heraud F, Hancock K, Sharma A, Cochrane B, Roussos A, Le Lievre C, Blakey J, Bosnic-Anticevich S, Carter V, Catanzariti A, Ghisla C, Hew M, Ko B, Le T, Leong P, McDonald VM, Lau CM, Perret JL, Pullen R, Ranasinghe K, Soriano JB, Stewart D, van Melle M, Wiseman R, Price D.   +28 more
europepmc   +1 more source