Results 131 to 140 of about 54,157 (345)
P622: NIPS dilemma in the context of consanguinity: Considerations for counseling [PDF]
, 2023 Noura Osman +3 more
openalex +1 more source
Advanced Science, EarlyView.This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård +19 more
wiley +1 more source
A Modular and Programmable Cas13d Platform for RNA Single Nucleotide Variant Detection
Advanced Science, EarlyView.A scenario‐guided Cas13d platform enables configurable single nucleotide variant ribonucleic acid diagnostics through rule‐based guide design and ribonucleic acid binding domain engineering, supporting amplification‐free ultrasensitive detection and amplification‐coupled robust detection for accurate mutation classification in clinical tumor specimens.
Zeyu Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
Mitochondrial DNA. Part B. Resources, 2019 Flowering cherries are domesticated to cultivars by multiple hybridization from some original species, and there formed various adaptive abilities. Herein, we established the complete chloroplast genome of Prunus campanulata x kanzakura ‘Praecox’.
Yuzhen Zhou +4 more
doaj +1 more source
Pyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy
Advanced Science, EarlyView.Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.
Tianli Hao +12 more
wiley +1 more source
Consanguinity And Pregnancy Outcome Among Rural Pregnant Women of Belgaum District
National Journal of Community Medicine, 2012 Background: Although unions between close biological relatives are preferred in many parts of South India, there still is a large gap of knowledge of this feature of human kinship structure. So, the present study was conducted to know the prevalence and
Chandra S Metgud +2 more
doaj
The Professional Medical Journal, 2017 Introduction: The epidemiological literature is inconsistent in its findings onassociation of parental consanguinity & birth outcomes. Research studies rarely look into thekin relationship of the spouses as a possible risk factor for reproductive wastage includingintra uterine deaths (IUDs). Objective: To assess the effect of parental consanguinity
Dr. Khalida Naz Memon +1 more
openaire +2 more sources
Estimating the Total Pathogenic Allele Frequency of Autosomal Recessive Disorders in Case of Consanguinity [PDF]
, 2015 Marianne A. Jonker +5 more
openalex +1 more source
Advanced Science, EarlyView.This study demonstrates significantly reduced Lkb1 expression in CD11c+ cells in chronic pancreatitis (CP) patients and animal models. Lkb1 deletion enhances CD11c+CD206+ macrophage infiltration and reprograms pancreatic stellate cells (PSCs) via OSM signaling.
Wenqing Zhang +10 more
wiley +1 more source