Results 51 to 60 of about 211,740 (219)

Conference Talk. Bertelsmann Policy Brief 04.2019 [PDF]

, 2019
Commission President Ursula von der Leyen has announced a two-year Conference on the Future of Europe. Even citizens ought to participate. But how? In order to make participatory democracy a reality, it is essential to avoid only paying lip-service to ...
Hierlemann, Dominik
core  

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Core competencies for pain management: results of an interprofessional consensus summit. [PDF]

, 2013
ObjectiveThe objective of this project was to develop core competencies in pain assessment and management for prelicensure health professional education. Such core pain competencies common to all prelicensure health professionals have not been previously
Bakerjian, Debra, Ballantyne, Jane C, Carr, Daniel B, Chou, Roger, Courtenay, Molly, Djukic, Maja, Fishman, Scott M, Gordon, Debra B, Herr, Keela, Koebner, Ian J, Lucas Arwood, Ellyn, Mongoven, Jennifer M, Murinson, Beth B, Paice, Judith A, Prasad, Ravi, Singh, Naileshni, Sluka, Kathleen A, St Marie, Barbara, Stevens, Bonnie J, Strassels, Scott A, Watt-Watson, Judy, Young, Heather M   +21 more
core   +1 more source

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

If citizens have a voice, who's listening? Lessons from recent citizen consultation experiments for the European Union. CEPS EPIN Working Paper No. 24, 12 June 2009 [PDF]

, 2009
Are European Union institutions, as they claim, really listening to citizens thanks to more ‘deliberative’ consultation tools? The European Commission and the European Parliament in particular have committed themselves to engaging in a dialogue with ...
Boucher, Stephen.
core  

Biomechanical Phenotyping Reveals Unique Mechanobiological Signatures of Early‐Onset Colorectal Cancer

Advanced Science, EarlyView.
This study identifies a unique physical signature of colorectal cancer in younger adults: their tissues are mechanically stiffer than those in older patients with the same cancer. Furthermore, stromal remodeling in early‐onset colorectal cancer promotes epithelial mechanotransduction and proliferation, showing how mechanical alterations in the tissue ...
Nicole C. Huning, Munir H. Buhaya, Victor V. Nguyen, Afeefah Khazi‐Syed, Haider A. Ali, Adil Khan, Angela Fan, Robert C. Fisher, Zhikai Chi, Indu Raman, Guangchun Chen, Chengsong Zhu, Mengxi Yu, Andrew R. Jamieson, Sara Roccabianca, Victor D. Varner, Cheryl M. Lewis, Emina H. Huang, Jacopo Ferruzzi   +18 more
wiley   +1 more source

The Measure of Meetings: Forums, Deliberation, and Cultural Policy [PDF]

This research seeks to answer the question: “Do meetings matter for advancing cultural policy?” The question is approached theoretically and comparatively by examining the broader literature on policy making, as well specific case studies of meetings in ...
Stephanie Hinton, Steven J. Tepper
core  

Bioinspired Tissue Transparency: Achieving Sclera‐to‐Cornea Transplantation

Advanced Science, EarlyView.
A bioinspired decellularization‐compression‐locking tactic (DCLT) is developed to transform human sclerae into transparent corneal substitutes. These clear, robust, and pro‐regenerative substitutes are capable of repairing complex corneal injuries, including chemical burns, keratoconus, and penetrating wounds, demonstrating their clinical potential to ...
Xiuli Sun, Long Zhao, Zhen Shi, Jingting Wang, Shang Yang, Xia Qi, Hengrui Zhang, Ting Wang, Weiyun Shi   +8 more
wiley   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Fora, networks and public examinations: the role and significance of public participation in the new regional plan for South East England [PDF]

, 2001
This paper overviews the main conceptual frameworks for understanding participatory approaches to land use planning and explores their utility in analysing the experience of a recent regional planning exercise in South East England.
Doak, Joe
core