Results 51 to 60 of about 1,184,096 (322)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Consensus of cyber-physical power systems based on multi-agent systems with communication constraints

Journal of Modern Power Systems and Clean Energy, 2019
The consensus protocol of cyber-physical power systems is proposed based on fractional-order multi-agent systems with communication constraints. It aims to enable each generator to reach a time-varying common rotor angle and rotor speed.
Chi Huang, Chengli Feng, Jinde Cao
doaj   +1 more source

Consensus ad idem: a protocol for development of consensus statements [PDF]

Canadian Journal of Surgery, 2013
No single group has the right to ignore a consensus of thoughtful opinion. Mollie Hunter (1922–2012) In this issue, we publish a consensus report from the Clinical Practice Committee of the Canadian Association of General Surgeons regarding Clostridium difficile. Medical use of the word “consensus” is evolving.
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

PnV: An Efficient Parallel Consensus Protocol Integrating Proof and Voting

Applied Sciences
Consensus protocols, as crucial components of blockchain technology, play a vital role in ensuring data consistency among distributed nodes. However, the existing voting-based and proof-based consensus protocols encounter scalability issues within the ...
Han Wang, Hui Li, Ping Fan, Jian Kang, Selwyn Deng, Xiang Zhu   +5 more
doaj   +1 more source

Innovative Application of Blockchain Technology for Digital Recipe Copyright Protection

Applied Sciences, 2023
With the advent of the digital age, traditional lifestyle activities, such as reading books, referencing recipes, and enjoying music, have progressively transitioned from offline to online.
Linlu Zhang, Shuxian Liu, Chengji Ma, Tingting Su   +3 more
doaj   +1 more source

Distributed Weight Selection in Consensus Protocols by Schatten Norm Minimization

, 2014
In average consensus protocols, nodes in a network perform an iterative weighted average of their estimates and those of their neighbors. The protocol converges to the average of initial estimates of all nodes found in the network.
Avrachenkov, Konstantin, Chamie, Mahmoud El, Neglia, Giovanni   +2 more
core   +3 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

OSCMS: A Decentralized Open-Source Coordination Management System Using a Novel Triple-Blockchain Architecture

Applied Sciences, 2023
Open-source systems help to manage the rapid development of software, while governing open-source systems properly can effectively promote software and software engineering.
Jiakai Chen, Yishi Zhao, Xiao Chen
doaj   +1 more source