Results 91 to 100 of about 4,479,200 (302)

How informed is consent in vulnerable populations? Experience using a continuous consent process during the MDP301 vaginal microbicide trial in Mwanza, Tanzania. [PDF]

, 2010
BACKGROUND: HIV prevention trials conducted among disadvantaged vulnerable at-risk populations in developing countries present unique ethical dilemmas. A key concern in bioethics is the validity of informed consent for trial participation obtained from ...
Soteli, Selephina, Kavit, N, Stella Kasindi, Pool, Robert, Hayes, Richard J., Selephina Soteli, Shagi, Charles, Lees, S., Pool, R, Shagi, C, Lisa Vallely, Sheena McCormack, Kasindi, S., Hayes, Richard J, Soteli, S, Lees, Shelley, McCormack, S., Soteli, S., Vallely, L ; https://orcid.org/, Kavit, N., The Microbicides Development Programme, Vallely, Andrew, Hayes, R.J., Charles Shagi, Kavit, Natujwa, Shagi, C., Lees, SS, McCormack, Sheena, Shelley Lees, Vallely, A., Pool, R., Microbicides Development Programme (MDP), Richard J Hayes, ?, ?, null null, Vallely, A ; https://orcid.org/, Kasindi, S, Kasindi, Stella, Vallely, L., Mccormack, S, Vallely, Lisa, Andrew Vallely, Natujwa Kavit, Robert Pool, Hayes, R, Soteli Selephina, Lees Shelley, Kasindi Stella, McCormack Sheena, Kavit Natujwa, Vallely Andrew, Hayes Richard J, Shagi Charles, Vallely Lisa, Pool Robert   +54 more
core   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mistreatment in healthcare: peripartum experience in a Tunisian maternityAJOG Global Reports at a Glance

AJOG Global Reports
Background: Mistreatment in healthcare is defined by the set of behaviors, acts, and omissions committed by the healthcare providers on patients. Pregnant women can be exposed to this behavior during pregnancy, childbirth, and the postpartum period.
Haithem Aloui, MD, Hatem Frikha, MD, Rami Hammami, MD, Amal Chermiti, MD, Hassine Saber Abouda, MD, Mohamed Badis Channoufi, PhD, Abir Karoui, PhD   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Module Two: Informed Consent

, 2005
The objective of this module is to familiarise you with the concept of informed consent, its ethical basis, its elements, and typical problems that are encountered even by the most well intentioned researchers when trying to achieve genuine informed ...
Andanda, Pamela
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Are We Ready for Whole Population Genomic Sequencing of Asymptomatic Newborns?

Pharmacogenomics and Personalized Medicine, 2023
Danya F Vears,1,2 Julian Savulescu,3– 6 John Christodoulou,1,2 Meaghan Wall,7 Ainsley J Newson8 1Murdoch Children’s Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia; 2University of Melbourne, Melbourne, Victoria, 3052 ...
Vears DF, Savulescu J, Christodoulou J, Wall M, Newson AJ   +4 more
doaj  

Consenting agents: semi-autonomous interactions for ubiquitous consent

, 2014
Ubiquitous computing, given a regulatory environment that seems to favor consent as a way to empower citizens, introduces the possibility of users being asked to make consent decisions in numerous everyday scenarios such as entering a supermarket or ...
Enrico Gerding, Gerding, Enrico, schraefel, m.c., Gomer, Richard Charles, M. C. schraefel, Richard Gomer   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Facial Recognition at the Fitness Center Under the General Data Protection Regulation Article 9(1) and 9(2)(a)

交大法學評論
There are significant concerns regarding the legitimacy of biometric data processing within the European Union. Therefore, it is imperative that facial data processing adheres to the criteria and standards outlined in the General Data Protection ...
Daria Bulgakova , Valentyna Bulgakova
doaj