Advanced Science, EarlyView.This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang +12 more
wiley +1 more source
A Near-Telomere-to-Telomere Genome Assembly of the Spotted Seal (<i>Phoca largha</i>) Reveals Genomic Architecture Underlying Skin and Fur Adaptation. [PDF]
Int J Mol SciZhou M +5 more
europepmc +1 more source
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Behavioral convergence under urbanization: An overlooked dimension of biotic homogenization. [PDF]
PLoS BiolMikula P, Blumstein DT, Tryjanowski P.
europepmc +1 more source
Assessment of a baloxavir marboxil treatment protocol for high pathogenicity avian influenza in Okinawa Rails, an endangered species endemic to Japan. [PDF]
PLoS OneMiki M +11 more
europepmc +1 more source
AI-Enhanced Virtual LIG-IoT Sensor Framework for Microclimatic Stress Prediction in <i>Vasconcellea stipulata</i> (Toronche) from Southern Ecuador. [PDF]
Sensors (Basel)Cuenca-Sánchez A, Pantoja-Suárez F.
europepmc +1 more source
Climatic Variables as Drivers of <i>Pterocarpus erinaceus</i> (Fabaceae): Distribution and the Implications of Climate Change. [PDF]
Ecol EvolSari İ +4 more
europepmc +1 more source
Molecular Regulators of In Vitro Regeneration in Wheat: Roles of Morphogenic Factors in Transformation, Genome Editing, and Breeding. [PDF]
Int J Mol SciKowalik S, Samoń M, Przyborowski M.
europepmc +1 more source