Results 91 to 100 of about 53,682 (268)

Conservative restorations that are made to last [PDF]

British Dental Journal, 2020
openaire   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

Source Tracing for Pollutants in River Channels Based on a Physics‐Informed Neural Network

Water Resources Research
The river pollutant traceability problem represents a critical challenge in environmental monitoring and water resource management. In this work, we propose an approach based on a physics‐informed neural network (PINN) for identifying key parameters of ...
Xu Zhao, Haifei Liu, Fei Leng, Wei Yang, Xinan Yin, Yujun Yi   +5 more
doaj   +1 more source

Ecological water replenishment reshapes the river microbiome along an urban-rural gradient: Enhanced diversity but compromised stability

Journal of Hydrology: Regional Studies
Study region: Yongding River Basin, a critical ecological corridor in the Beijing-Tianjin-Hebei region of northern China, characterized by distinct urban-rural gradients.
Hongyuan Tian, Yujia Zhai, Jichen Qiu, Tianrui Cui, Tian Xie, Junhong Bai, Baoshan Cui   +6 more
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Predicting the Potential Suitable Habitat of Solanum rostratum in China Using the Biomod2 Ensemble Modeling Framework

Plants
Solanum rostratum Dunal is a highly invasive species with strong environmental adaptability and reproductive capacity, posing serious threats to agroforestry ecosystems and human health. In this study, we compiled occurrence records of S.
Jiajie Wang, Jingdong Zhao, Lina Jiang, Xuejiao Han, Yuanjun Zhu   +4 more
doaj   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Nanotechnology for coral reef conservation, restoration and rehabilitation

Nature Nanotechnology, 2023
Liza Roger, Nastassja Lewinski, Hollie Putnam, Shaochen Chen, Daniel Roxbury, Martin Tresguerres, Daniel Wangpraseurt   +6 more
openaire   +4 more sources

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source