Results 51 to 60 of about 53,682 (268)

Spatial-Temporal Process of Land Use/Land Cover and Desertification in the Circum-Tarim Basin during 1990–2020

Land
The problem of desertification in the Tarim Basin, an area with a unique geography and climatic conditions, has received extensive research attention not only in China but also around the world.
Xiaoming Cao, Mengchun Cui, Lei Xi, Yiming Feng   +3 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Interactions between phytoplankton and bacterioplankton communities in Caohai plateau lake, revealed by environmental DNA metagenomics

BMC Microbiology
Phytoplankton-bacterioplankton interactions critically influence aquatic ecosystem stability, yet their dynamics remain poorly understood in eutrophic plateau lakes.
Yunchuan Long, Jin Guo, Liangliang Dai, Juan Jiang   +3 more
doaj   +1 more source

Potential Distribution and Response to Climate Change in Puccinellia tenuiflora in China Projected Using Optimized MaxEnt Model

Biology
Global climate change is accelerating and human pressures are intensifying, exerting profound impacts on biodiversity and ecosystem service functions.
Hao Yang, Xiaoting Wei, Manyin Zhang, Jinxin Zhang   +3 more
doaj   +1 more source

Characterizing the composition, metabolism and physiological functions of the fatty liver in Rana omeimontis tadpoles

Frontiers in Zoology, 2019
Background Fat storage is required for the life cycle of many organisms. The primary fat depot for most vertebrates is white adipose tissue. However, in primitive vertebrates (e.g., agnathan group and elasmobranchs), the liver is usually responsible for ...
Wei Zhu, Meihua Zhang, Liming Chang, Wenbo Zhu, Cheng Li, Feng Xie, Huan Zhang, Tian Zhao, Jianping Jiang   +8 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

A Restoring Paradigm of Estuarine Wetland Based on Resilience

Ecosystem Health and Sustainability
Estuarine wetlands provide various critical ecosystem services, including providing habitats for organisms, biodiversity conservation, and nutrient cycling and are important regions for human life and economic development.
Henian Wang, Manyin Zhang, Lijuan Cui, Ziliang Guo, Daan Wang, Weiwei Liu   +5 more
doaj   +1 more source

Unveiling the Occupational Exposure to Microbial Contamination in Conservation-Restoration Settings. [PDF]

Microorganisms, 2022
Viegas C, Cervantes R, Dias M, Gomes B, Pena P, Carolino E, Twarużek M, Kosicki R, Soszczyńska E, Viegas S, Caetano LA, Pinheiro AC.   +11 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source