Results 101 to 110 of about 1,779,244 (346)

The Direzione Generale per gli Affari Generali, il Bilancio, le Risorse Umane e la Formazione, in the re-organization of the Ministero per i Beni e le Attività Culturali: institutional purposes bent to Human Resources and Training

open access: yesConservation Science in Cultural Heritage, 2004
The plan for the training for 2005 is presented as part of the re-organization of the Ministry for Cultural Heritage and Activities and of the General Management for General Affairs, for the Budget, Human Resources and Training, in particular it is a ...
Alfredo Giacomazzi
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

open access: yesMolecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo   +18 more
wiley   +1 more source

Technical and Scientific Research as an Aid to Art Historians in the Attribution of Art Works

open access: yesConservation Science in Cultural Heritage, 2017
The present work underlines the importance of an objective evaluation in the study of constituent materials and execution techniques, as well as an examination of the state of conservation of some paintings, performed during the corresponding restoration
Mauro Sebastianelli
doaj   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

Conservation and the genetics of populations

open access: yes, 2006
Authors of Guest Boxes. Preface. List of Symbols. PART I: INTRODUCTION. 1 Introduction. 1.1 Genetics and conservation. 1.2 What should we conserve?. 1.3 How should we conserve biodiversity?. 1.4 Applications of genetics to conservation. Guest Box 1 by L.
F. Allendorf, G. Luikart
semanticscholar   +1 more source

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