Results 101 to 110 of about 4,536,109 (357)
The Boston Medical and Surgical Journal, 1884 The advance of science is hindered not more by obstinacy than by fickleness. The skepticism which uses an honest crucible is a blessing; the skepticism which wields a club, and smashes old things indiscriminately because they are ancient, is a curse. Underneath its destructive malice is often a credulous and craven tenderness for anything which is new.
openaire +1 more source
Insights into a long life without cancer: The case of the bowhead whale
Molecular Oncology, EarlyView.Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley +1 more source
Art and environment as media for ecosustainability, ethics and aesthetics
Conservation Science in Cultural Heritage, 2012 “Art, both in a strict sense, but also in a broader sense, that is to say environmental and cultural heritage – considering, as it correctly should be, the environment with its individual compartments of air, soil and water – is indissolubly linked to ...
Salvatore Lorusso, Angela Braida
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
A note from the restoration world: the Raffaello completed?
Conservation Science in Cultural Heritage, 2002 History of a restoration work that had opened the way to a new, fascinating attribution hypothesis for a drawing that was considered a Giulio Romano’s work and today it is considered a Raffaello’s work, with a subsequently partial intervention of his ...
Pietro Livi
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FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Chemistry: our Life, our Future
Conservation Science in Cultural Heritage, 2017 In this note we look at a number of aspects relating to chemistry that have had a strong impact on the future of humanity. In particular, some technological innovations have been examined which have had a strong impact on daily life in general; the role ...
Ferruccio Trifirò
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Randomness Conservation over Algorithms [PDF]
, 2013 Current discrete randomness and information conservation inequalities are over total recursive functions, i.e. restricted to deterministic processing. This restriction implies that an algorithm can break algorithmic randomness conservation inequalities ...
Epstein, Samuel
core
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source