Results 181 to 190 of about 579 (246)

Catchment prioritization for freshwater mussel conservation in the Northeastern United States based on distribution modelling. [PDF]

PLoS One
O'Brien RSM, DiRenzo GV, Roy AH, Carmignani J, Quinones RM, Rogers JB, Swartz BI.   +6 more
europepmc   +1 more source

Common questions on conservation easements

, 2009
Jones, Jeff, author, Wombacher, William, author, Sherrod, Lynne, author, McMillian, Heather, author, Center for Collaborative Conservation, publisher   +4 more
openaire   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Climate change and California's terrestrial biodiversity. [PDF]

Proc Natl Acad Sci U S A
Harrison S, Franklin J, Hernandez RR, Ikegami M, Safford HD, Thorne JH.   +5 more
europepmc   +1 more source

Climate resilience through ecocultural stewardship. [PDF]

Proc Natl Acad Sci U S A
Hankins DL.
europepmc   +1 more source

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Why agree to a conservation easement? Understanding the decision of conservation easement granting

Landscape and Urban Planning, 2015
Abstract In the United States, the amount of land protected by conservation easements dramatically increased between 2000 and 2010. As this mechanism for private land conservation continues to draw the attention of scientists, professionals, and policy makers, more information is needed on the landowner motivations and the variables affecting the ...
Charles Chancellor, James Farmer, Doug Knapp   +2 more
exaly   +2 more sources

Conservation easements: biodiversity protection and private use.

Conservation Biology, 2007
Abstract:  Conservation easements are one of the primary tools for conserving biodiversity on private land. Despite their increasing use, little quantitative data are available on what species and habitats conservation easements aim to protect, how much structural development they allow, or what types of land ...
Adena R Rissman, Adina Merenlender, Peter M. Kareiva   +2 more
exaly   +3 more sources