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Advanced Materials, EarlyView.Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode +16 more
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Current Biology, 2021
Natural populations currently face a wide variety of threats including climate change, habitat loss, over-harvesting, invasive species and disease. The most recent report by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) found that ecosystems have declined by approximately 50% relative to historical ...
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Natural populations currently face a wide variety of threats including climate change, habitat loss, over-harvesting, invasive species and disease. The most recent report by the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES) found that ecosystems have declined by approximately 50% relative to historical ...
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Where's the Conservation in Conservation Genetics?
Conservation Biology, 2008The molecular techniques for producing the type and quantity of data required for conservation studies are now available, and the number of statistical methods applicable to such genetic data is constantly growing. We propose two clear objectives critical to ensconcing conservation genetics as a mature and indispensable discipline: the regular and ...
Vernesi, Cristiano +5 more
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Annual Review of Genetics, 1995
Inbreeding depression, accumulation and loss of deleterious mutations, loss of genetic variation in small populations, genetic adaptation to captivity and its effect on reintroduction success, and outbreeding depression are reviewed. The impact of genetic factors in endangerment and extinction has been underestimated in some recent publications ...
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Inbreeding depression, accumulation and loss of deleterious mutations, loss of genetic variation in small populations, genetic adaptation to captivity and its effect on reintroduction success, and outbreeding depression are reviewed. The impact of genetic factors in endangerment and extinction has been underestimated in some recent publications ...
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From Conservation Genetics to Conservation Genomics
Annals of the New York Academy of Sciences, 2009Although the application of population and evolutionary genetic theory and methods to address issues of conservation relevance has a long history, the formalization of conservation genetics as a research field is still relatively recent. One of the periodic catalysts for increased research effort in the field has been advances in molecular technologies,
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Genomics and conservation genetics
Trends in Ecology & Evolution, 2006In large part, the relevance of genetics to conservation rests on the premise that neutral marker variation in populations reflects levels of detrimental and adaptive genetic variation. Despite its prominence, this tenet has been difficult to evaluate, until now.
Michael H, Kohn +3 more
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2004
Conservation genetics is an interdisciplinary science that aims to apply genetic methods to the conservation and restoration of biodiversity. In recent years, the field has been expanding due to advances in technologies and related disciplines, including genomics.
George Amato +3 more
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Conservation genetics is an interdisciplinary science that aims to apply genetic methods to the conservation and restoration of biodiversity. In recent years, the field has been expanding due to advances in technologies and related disciplines, including genomics.
George Amato +3 more
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Conservation genetics in transition to conservation genomics
Trends in Genetics, 2010Over the past twenty years conservation genetics has progressed from being mainly a theory-based field of population biology to a full-grown empirical discipline. Technological developments in molecular genetics have led to extensive use of neutral molecular markers such as microsatellites in conservation biology.
Ouborg, N. Joop +4 more
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Agriculture, Ecosystems & Environment, 1992
Abstract The basic sciences of genetics and ecology have long played a vital role in agriculture. New technologies spawning a gene revolution promise to revolutionize agricultural genetics. The opportunities to utilize these new techniques, along with standard methods of animal and plant breeding, are great for agriculture, conservation biology, and ...
David S. Woodruff, Graham A.E. Gall
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Abstract The basic sciences of genetics and ecology have long played a vital role in agriculture. New technologies spawning a gene revolution promise to revolutionize agricultural genetics. The opportunities to utilize these new techniques, along with standard methods of animal and plant breeding, are great for agriculture, conservation biology, and ...
David S. Woodruff, Graham A.E. Gall
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