First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria
Advanced Science, EarlyView.We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena +5 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that in high‐alloy systems, nanoclusters with high solute tolerance can effectively suppress compositional segregation. This mitigation leads to a concurrent 18.7% increase in strength and 41.5% improvement in ductility, which is attributed to a shear‐bypass synergistic strengthening mechanism. The findings provide a new pathway
Wei Yu +10 more
wiley +1 more source
Integrability and Diffeomorphisms on Target Space
Symmetry, Integrability and Geometry: Methods and Applications, 2007 We briefly review the concepts of generalized zero curvature conditions and integrability in higher dimensions, where integrability in this context is related to the existence of infinitely many conservation laws.
Christoph Adam +2 more
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A Hierarchy of Probability, Fluid and Generalized Densities for the Eulerian Velocivolumetric Description of Fluid Flow, for New Families of Conservation Laws. [PDF]
Entropy (Basel), 2022 Niven RK.
europepmc +1 more source
Physics‐Embedded Neural Network: A Novel Approach to Design Polymeric Materials
Advanced Science, EarlyView.Traditional black‐box models for polymer mechanics rely solely on data and lack physical interpretability. This work presents a physics‐embedded neural network (PENN) that integrates constitutive equations into machine learning. The approach ensures reliable stress predictions, provides interpretable parameters, and enables performance‐driven, inverse ...
Siqi Zhan +8 more
wiley +1 more source
Conservation laws for electron vortices in strong-field ionisation. [PDF]
Eur Phys J D At Mol Opt Phys, 2021 Kang Y +5 more
europepmc +1 more source
Nucleation Kinetics Reveals a Distinct Biological Function Space of Biomolecular Condensates
Advanced Science, EarlyView.This study utilizes microfluidics to quantify the nucleation rates of dense liquid phases within dilute solutions and of the reverse process, in which dilute voids nucleate inside condensates. The interfacial tension is identified as the key determinant of both processes.
Leif‐Thore Deck +5 more
wiley +1 more source
A numerical approach for detecting switch-like bistability in mass action chemical reaction networks with conservation laws. [PDF]
BMC Bioinformatics, 2022 Reyes BC, Otero-Muras I, Petyuk VA.
europepmc +1 more source
Deformation‐Induced Formation of Stray Grains in Additive Manufacturing of Single Crystals
Advanced Science, EarlyView.Stray grain formation severely limits the additive manufacturing of single‐crystal alloys. By integrating in situ synchrotron techniques, ex situ characterization, and multi‐scale multi‐physics modeling, the authors reveal that stray grains originate from dislocations at the solid‐liquid interface, rather than thermal supercooling in conventional ...
Dongsheng Zhang +11 more
wiley +1 more source
Nonlinear Analysis, 2013 This paper studies the Zakharov equation with power law nonlinearity. The traveling wave hypothesis is applied to obtain the 1-soliton solution of this equation.
Richard Morris +2 more
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