Results 131 to 140 of about 168,519,929 (271)

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Bridging the Gap Between Legal Designation and Management Outcomes: Evidence from a Newly Established Marine Protected Area in Thailand. [PDF]

Environ Manage
Satumanatpan S, Praisankul S, Chankum P, Singin P, Pantorn T.   +4 more
europepmc   +1 more source

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Stewardship of the Plains : a partnership strategic plan to conserve and sustain our natural resources.

, 1996
Shipping list no.: 96-0369-P."The Conservation Partnership for the Northern Plains: Local Conservation Districts, State Conservation Agencies."Cover title.Mode of access: Internet.
United States. Natural Resources Conservation Service.
core  

Conservation of Natural Resources [PDF]

Nature, 1958
openaire   +1 more source

Towards the Establishment of a Sea Urchin Sperm Biobank: Key Challenges and Opportunities for the Conservation and Sustainable Aquaculture of <i>Paracentrotus lividus</i>. [PDF]

Animals (Basel)
Antenucci E, Di Iorio M, Santoianni C, Mastronardi A, Cofelice M, Lopez F, Rosati S, Maiuro L, Sorrentino E, Carone G, Zizzo N, Bozkurt Y, Roncarati A, Iaffaldano N.   +13 more
europepmc   +1 more source

Renal Tubular Epithelial CRLF1 Interacts With ITGB1 to Accelerate Fibrosis During the Transition From AKI to CKD

Advanced Science, EarlyView.
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang, Yan Zhang, Fang Bai, Shankui Qian, Feng Feng, Fangyi Lu, Jiahui Fan, Kuipeng Yu, Xiangdong Yang   +8 more
wiley   +1 more source

Behavioral Structure, Activity Rhythm and Relationships to the Conservation and Welfare of Tibetan Fox in Tibet Plateau of China. [PDF]

Vet Sci
Wang X, Lu X, Wu J, Wang J, Sangzhu Z, Meng X.   +5 more
europepmc   +1 more source

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics‐Based Optimization with Limited Activity Data

Advanced Science, EarlyView.
Using a minimal set of experimentally labeled antimicrobial and non‐antimicrobial peptides, we reconstruct the effective lipid composition of a pathogenic membrane ‐demonstrated at the example of bacterial membranes‐ through a physics‐based evolutionary molecular dynamics (Evo‐MD) approach. Optimization based on peptide insertion reveals broad‐spectrum
Maximilian Krebs, Herre Jelger Risselada
wiley   +1 more source

Complete mitochondrial genome and phylogenetic analysis of Taiwanese Wedgefish (<i>Rhynchobatus immaculatus</i>). [PDF]

Mitochondrial DNA B Resour
Wang S, Zhu X, Zhao L, Liu M.
europepmc   +1 more source