Results 271 to 280 of about 1,068,650 (333)

Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

open access: yesAdvanced Science, EarlyView.
Acute myeloid leukemia (AML) remains a therapeutic challenge due to its heterogeneity and limited targets. Here, multi‐omics analyses are utilized, and it is revealed that AML cells, particularly the FLT3‐ITD+ subtype, undergo chaperone‐mediated ER stress, inducing surface translocation of ER chaperones.
Yimin Zhou   +13 more
wiley   +1 more source

Accurate Generation of Conformational Ensembles for Intrinsically Disordered Proteins with IDPFold

open access: yesAdvanced Science, EarlyView.
In brief: IDPFold predicts the conformational ensembles of intrinsically disordered proteins (IDPs) from their amino acid sequences. The atomic structures generated by IDPFold offer crucial insights into the intricate relationship between IDP structures and their diverse biological functions.2 Abstract Intrinsically disordered proteins (IDPs) play ...
Junjie Zhu   +10 more
wiley   +1 more source

Population structure and inter-species admixture within a likely extinct yet formerly widespread Hawaiian honeycreeper. [PDF]

open access: yesBiol Lett
Przelomska NAS   +8 more
europepmc   +1 more source

Diversity and Ecological Potentials of Marine Viruses Inhabiting Continental Shelf Seas

open access: yesAdvanced Science, EarlyView.
To the best of the knowledge, this study provides the largest viral genome dataset from a continental shelf sea. It reveals that over half of vOTUs are novel, highlighting the remarkable viral novelty in the eastern continental shelf seas of China (ECSSC).
Xiaoyue Guo   +9 more
wiley   +1 more source

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