Results 31 to 40 of about 1,057,758 (327)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Assessment of Streams and Watersheds in Illinois: Development of a Stream Classification System and Fish Sampling Protocols [PDF]

, 2003
Final Report issued October 1, 2003.Report issued on: October 1, 2003INHS Technical Report prepared for Illinois Department of Natural Resources, Office of Resource Conservation and Illinois Environmental Protection Agency, Bureau of ...
Dolan, C.R., Holtrop, Ann Marie
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Prediction of the joint impacts of sea level rise and land development on distribution patterns of mangrove communities

Forest Ecosystems, 2023
Mangrove distribution along shorelines shows distinct zonation patterns; thus, different communities may face various influences from sea level rise (SLR) and land use.
Shanshan Liang, Wenjia Hu, Peiqiang Wu, Jianbu Wang, Shangke Su, Guangcheng Chen, Jianguo Du, Wenhua Liu, Bin Chen   +8 more
doaj   +1 more source

The use of mangroves for aquaculture: Cambodia. [PDF]

, 2004
Natural conditions of the coastal and ecosystems of Cambodia have made this country rich of biodiversity resources. Cambodia’s 435 km coastline is covered with large estuaries with about 85,100 ha of mangrove forests (Nelson 1999).
Song, Srun Lim
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Decadal evolution of a sandy beach adjacent to a river mouth under natural drivers and human impacts

Frontiers in Marine Science
As escalating environmental pressures threaten the world’s beaches, understanding the driving factors influencing their geomorphological changes is of critical global importance. This study focuses on the morphological changes of Sigeng beach adjacent to
Gen Liu, Gen Liu, Gen Liu, Feng Cai, Feng Cai, Hongshuai Qi, Hongshuai Qi, Jianhui Liu, Jianhui Liu, Chao Cao, Chao Cao, Shaohua Zhao, Shaohua Zhao, Yanyu He, Yanyu He, Jun Zhu, Jun Zhu, Chao Yin, Wenyuan Mo   +18 more
doaj   +1 more source

Interaction between Molten Al‐Killed Mn–B Steel and Carbon‐Bonded MgO Refractories Based on Recyclates

Advanced Engineering Materials, EarlyView.
High‐temperature interactions between low‐sulfur Al‐killed Mn–B steel and MgO–C refractories (0 and 50 wt% recyclates) are studied via finger immersion tests (1600 °C). Surface‐active elements influence infiltration. MgO/CaS layer forms, along with spinel and calcium silicate.
Matheus Roberto Bellé, Lukas Neubert, Anton Yehorov, Till M. J. Stadtmüller, Christos G. Aneziris, Olena Volkova   +5 more
wiley   +1 more source

Property Regimes in Resource Conservation-A Framework for Analysis [PDF]

This paper develops a conceptual framework for analysing property regimes in conservation of natural resources. Human beings interaction with their environment is governed through institutions of property; therefore they play an important role in the ...
Hasan, Lubna
core   +4 more sources