Results 61 to 70 of about 784,465 (187)

Computational Modeling and Experimental Approaches for Understanding the Mechanisms of [FeFe]‐Hydrogenase

Advanced Science, EarlyView.
A comprehensive understanding of hydrogenases' structures and catalytic mechanisms is crucial to replicate and exceed their performance. Computational modeling has proven to be a powerful tool for elucidating the reduction chemistry of [FeFe]‐hydrogenases. This review overviews recent computational and experimental efforts, focusing on DFT calculations
Chang‐Ah Kim, Jiabin Wu, Jun Zhu, Huaiguang Li, Zhihai Ke   +4 more
wiley   +1 more source

GDC: Integration of Multi‐Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss

Advanced Science, EarlyView.
Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng, Xuegang Wang, Mingjun Zhong, Jia Geng, Wenjian Li, Kanglu Pei, Jing Wang, Lanchen Wang, Yu Lu, Jing Cheng, Fengxiao Bu, Huijun Yuan   +11 more
wiley   +1 more source

Soil Series of the Gordon Natural Area [PDF]

, 2014
Official Soil Series Descriptions. Available URL: http://soils.usda.gov/technical/classification/osd/index.html [Accessed 28 April 2014].
Soil Survey Staff, Natural Resources Conservation Service, United States Department of Agriculture
core   +1 more source

Maintaining standing stones benefits biodiversity in lowland heathland [PDF]

, 2018
The exploitation of natural resources by people generally has detrimental effects on nature but in some cases anthropogenic activities can result in changes to the natural environment that produce new habitats and increase biodiversity. Understanding and
Agnoletti, Burl, Dudley, Emma Shepheard-Walwyn, Gaillard, Heil, Howard, Kent, Key, Kirby, Krebs, Media, Moran, Pratt, Shonil A. Bhagwat, Taylor, Whittaker, Yates   +17 more
core   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Federal Standards and Procedures for the National Watershed Boundary Dataset (WBD) (4 ed.) [PDF]

, 2013
The Watershed Boundary Dataset (WBD) is a comprehensive aggregated collection of hydrologic unit data consistent with the national criteria for delineation and resolution. This document establishes Federal standards and procedures for creating the WBD as
U.S. Department of Agriculture, Natural Resources and Conservation Service, U.S. Geological Survey   +1 more
core   +1 more source

Natural resources conservation management and strategies in agriculture [PDF]

, 2013
This paper suggests a holistic framework for assessment and improvement of management strategies for conservation of natural resources in agriculture.
Bachev, Hrabrin
core   +1 more source

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Advanced Science, EarlyView.
MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang   +15 more
wiley   +1 more source

Inhibition of RACK1‐Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Schematic diagram showing the potential mechanism of bigelovin on the activation of NLRP3 inflammasome Bigelovin may inhibit activated protein C kinase 1 (RACK1) by directly binding with cys168 of RACK1. Bigelovin thus prevents oligomerization of NLRP3 (NLRP3 active conformation) and subsequent assembly of NLRP3 inflammasome, blocking the activation of
Jian Cui, Meng Yang, Chengli Yu, Haidong Zhang, Yuan Gong, Yang Hu, Yue Wang, Qingxin Yuan, An Pan, Jiepin Li, Yaowen Hu, Zecheng Jin, Xuemei Peng, Anyuan Wu, Junwei Wang, Qian Wang, Yinan Zhang, Lihong Hu   +17 more
wiley   +1 more source

HIC1 suppresses Tumor Progression and Enhances CD8+ T Cells Infiltration Through Promoting GSDMD‐induced Pyroptosis in Gastric Cancer

Advanced Science, EarlyView.
These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang, Wenqi Du, Lina Ding, Mengdi Wu, Dongsheng Pei   +4 more
wiley   +1 more source