Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System
Advanced Science, EarlyView.This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi +13 more
wiley +1 more source
Current practices in marine systematic conservation planning: protocol for a global scoping review. [PDF]
Open Res Eur, 2023 Fabbrizzi E +13 more
europepmc +1 more source
Squamscott Project Newfields Open Space Committee [PDF]
, 2003 Through the Newfields Open Space Committee (NOSC) the objectives under the Squamscott Project were to educate the citizens of Newfields on conservation options and estate planning, the goals and objectives of the NOSC, and to finalize a natural resource ...
Degnan, Tracy
core +1 more source
A Self‐Organized Liquid Reaction Container for Cellular Memory
Advanced Science, EarlyView.How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee +4 more
wiley +1 more source
Mapping suitable habitats for globally endangered raptors in Kenya: Integrating climate factors and conservation planning. [PDF]
Ecol Evol, 2023 Ngila PM +4 more
europepmc +1 more source
Advanced Science, EarlyView.This study presents the first telomere‐to‐telomere genomes and population resources for Diaporthe pathogens, uncovering the largest known fungal repertoire of secondary metabolite gene clusters. Structural variations and horizontal gene transfer drive cluster diversification, while specific rapidly evolving clusters control virulence, offering novel ...
Kainan Li +9 more
wiley +1 more source
Koala Genome Survey: An Open Data Resource to Improve Conservation Planning. [PDF]
Genes (Basel), 2023 Hogg CJ, Silver L, McLennan EA, Belov K.
europepmc +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Advanced Science, EarlyView.Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang +10 more
wiley +1 more source
The Impact of Spatial Heterogeneity in Land Use Practices and Aquifer Characteristics on Groundwater Conservation Policy Cost [PDF]
Estimation of agricultural policy cost for a given level of groundwater conservation requires the establishment of an accurate baseline condition. This is especially critical when the benefits and cost of any conservation program are generally estimated ...
Barbato, Lucia S. +6 more
core +1 more source