Results 51 to 60 of about 75,262 (210)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Commitment to environmental preservation in The Nglanggeran ancient volcano ecotourism area

International Journal of Applied Sciences in Tourism and Events
This study investigates the commitment to environmental preservation in the Nglanggeran Ancient Volcano Ecotourism Area, located in Gunungkidul, Yogyakarta, Indonesia.
Andreas Yogi Prasetyo, Eki Melina Widanti, Atika Nur Hidayah   +2 more
doaj   +1 more source

Effects of green initiatives on hotel performance in Kampala, Uganda: Evidence from a mixed-methods approach on 5-star hotels [PDF]

Zbornik radova Departmana za geografiju, turizam i hotelijerstvo
This study investigates the impact of green practices on hotel performance in four five-star hotels in Kampala (Kampala Serena Hotel, Sheraton Hotel, Commonwealth Resort Munyonyo, and Pearl of Africa Hotel). The green practices assessed include water and
Paapa Christopher
doaj   +1 more source

Factors that influence participation of Puerto Rican coffee farmers in conservation programs

Conservation Science and Practice, 2020
Sustainable, conservation‐oriented agricultural practices like shade coffee and agroforestry can enhance conservation objectives in tropical landscapes. Adoption of these practices, however, is influenced by numerous factors.
Tatiana M. Gladkikh, Jaime A. Collazo, Alejandro Torres‐Abreu, Angelica M. Reyes, Marysol Molina   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Looking for attitudes related to amphibian species decline: how are peer-reviewed publications of education activities compared to ecological research?

Anais da Academia Brasileira de Ciências
Biodiversity decline has been the focus of discussions in the last decade, especially on the amphibian species decline. After a scientometric analysis using international databases, we found that the number of peer-reviewed articles considering education
ROGER P. MORMUL, TAYLA D.S. MORMUL, GUSTAVO M.B. SANTOS, ANA R.A. SANTANA   +3 more
doaj   +1 more source

Measuring sustainability of conservation and conventional practices in maize production in Ghana

Journal of Agriculture and Environment for International Development, 2020
Scientists and researchers worldwide have recommended Conservation Agriculture as one that has the potential to promote sustainability in agriculture. This paper attempts to measure and compare the economic, social, and environmental sustainability of ...
Mavis Boimah, Akwasi Mensah-Bonsu, Yaw Osei-Asare, Daniel Bruce Sarpong   +3 more
doaj   +1 more source