Results 41 to 50 of about 142,634 (260)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Water Erosion Processes on the Geotouristic Trails of Serra da Bocaina National Park Coast, Rio de Janeiro State, Brazil

Soil Systems
Conservation units are strategic territories that have a high demand for public use, as they protect attractions of great scenic beauty, geodiversity sites, and numerous leisure areas.
Guilherme Marques de Lima, Antonio Jose Teixeira Guerra, Luana de Almeida Rangel, Colin A. Booth, Michael Augustine Fullen   +4 more
doaj   +1 more source

Extinction of mammalian populations in conservation units of the Brazilian Cerrado by inbreeding depression in stochastic environments

Genetics and Molecular Biology, 2008
Despite methodological and theoretical advances in conservation genetics, data on genetic variation on broad regional spatial scales are still scarce, leading conservation planners to use general heuristic or simulation models for an integrated analysis ...
Marcel Müller Fernandes Pereira da Silva, José Alexandre Felizola Diniz-Filho   +1 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Mapping the Available Water Capacity in tropical climate soils for soybean (Glycine max) cultivation in the state of Tocantins-Brazil

Revista Ambiente & Água, 2021
Brazilian soybean has undergone considerable economic growth. Its production depends on the demand for some inputs. One of these inputs is the soil water supply, which can be made artificially or obtained by natural rainfall. Knowledge of available water
André de Moura Andrade, Rui da Silva Andrade, Erich Collicchio   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Ant diversity (Hymenoptera: Formicidae) in Turvo State Park, municipality of Derrubadas, state of Rio Grande do Sul, Brazil

Brazilian Journal of Biology, 2021
The knowledge of ant assemblages that occurs in Conservation Units in the Atlantic Forest domain is a priority, considering the number of endemic species and the impacts that this biome has been suffering.
J. A. Lutinski, F. E. Dorneles, C. Guarda, C. J. Lutinski, M. A. Busato, R. Giovenardi, F. R. M. Garcia   +6 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A criação de áreas protegidas e os limites da conservação ambiental em Rondônia The creation of protected areas and the limits of environmental conservation in Rondônia

Ambiente & Sociedade, 1999
Este artigo analisa o processo de criação e proteção de unidades de conservação no Estado de Rondônia. Este processo tem tido o apoio financeiro e orientação programática do Banco Mundial através de diferentes programas de desenvolvimento regional desde ...
Marcos Pedlowski, Virginia Dale, Eraldo Matricardi   +2 more
doaj   +1 more source