Results 121 to 130 of about 3,724,602 (294)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Forum: Qualitative Social Research, 2009 Traditionally discussions of "diversity" in organizations either refer to an ideal "management" of a diverse workforce or to specific concerns of minorities. The term diversity, however, entails a growing number of translations.
Anja Ostendorp
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2012 Bu makalede, özellikle monoteist bir inanca sahip olanların, "varlık" a matuf temel argümanlarından birisi olan "gaye ve nizam" düşüncesi ile inanmayanların hem bu düşünceye bir cevap olarak dile getirdikleri hem de bu konu ile ilgili aslında temel ...
Abdullah Pakoğlu
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Large-scale File System Design and Architecture
Acta Polytechnica, 2002 This paper deals with design issues of a global file system, aiming to provide transparent data availability, security against loss and disclosure, and support for mobile and disconnected clients.First, the paper surveys general challenges and ...
V. Dynda, P. Rydlo
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Zinc Supplementation in Children with Acute Diarrhea
Journal of Rawalpindi Medical College, 2009 Background: To evaluate the effect of zinc supplementation on the outcome of acute diarrhea by comparing it with standard management of acute diarrhea in children. Methods: In this interventional study, total 100 patients, 6 months to 5 years of age were
Shehla Choudhry
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source