Results 31 to 40 of about 1,215,262 (268)

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

Frontiers in Pharmacology
Heart failure is the most costly cardiovascular disorder. New treatments are urgently needed. This study aims to evaluate the safety, pharmacokinetics, and pharmacodynamic profile of HEC95468, a soluble guanylate cyclase (sGC) stimulator, in healthy ...
Yu-zhou Gui, Yu-zhou Gui, Wei Wang, Wei Wang, Qing-qing Wu, Qing-qing Wu, Qi-chen Ding, Qi-chen Ding, Hong-jie Qian, Hong-jie Qian, Qiu-bei Lu, Ying-jun Zhang, Yu-lei Zhuang, Li Deng, Ying-lin Zuo, Lin Luo, Jing-ying Jia, Jing-ying Jia   +17 more
doaj   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Sinomenine Regulates PSMB9 to Mediate Therapeutic Effects in Rheumatoid Arthritis

Cells
Rheumatoid arthritis (RA) is a systemic immune-related disease characterized by chronic synovial inflammation and progressive joint destruction. However, the molecular mechanisms and diagnostic biomarkers underlying RA remain unclear.
Cui Zhang, Chonkit Lio, Nana Li, Yang Yu, Jinfang Luo   +4 more
doaj   +1 more source

Distribution and consistency of Ancona and Livorno poultry breed in Central Italy

Italian Journal of Animal Science, 2020
Nowadays most of the Italian chickens’ breeds are replaced with commercial hybrids characterised by higher productive performance. However, the safeguard of biodiversity and consequently the genetic variability are a very important issue, and for this ...
Alice Cartoni Mancinelli, Alessandro Franzoni, Alessandro Dal Bosco, Achille Schiavone, Federica Mannelli, Margherita Marzoni, Cesare Castellini   +6 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

The perceived fairness and consistency of disciplinary practices in selected police stations

SA Journal of Human Resource Management
Orientation: The fair and consistent application of disciplinary policies and procedures in government institutions is vital to nurture professional, ethical and bias-free workspace.
Thabo A. Mabusela, Thulile L. Ngonyama-Ndou, Mphoreng M. Mmako   +2 more
doaj   +1 more source

Inconsistency between ANB Angle and Wits Appraisal in the Turkish Population

Turkish Journal of Orthodontics, 2015
Objective:The aim of this study was to investigate the cephalometric parameters that impair the consistency between the Wits and ANB measurements, which are used in the determination of anteroposterior jaw relationships by logistic regression analysis in
Gökhan Serhat Duran, Furkan Dindaroğlu
doaj   +1 more source

Iterative learning consistency control for multi-agent systems with forgetting factors under random actuator failures [PDF]

Proceedings of the Estonian Academy of Sciences
For the discrete linear multi-agent systems with random actuator faults and system disturbances, an iterative learning control strategy with the forgetting factor is proposed. Firstly, the random variation of actuator faults with the number of iterations
Yuhan Li, Xingjian Fu
doaj   +1 more source