Results 71 to 80 of about 1,215,262 (268)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Bounded Laplace Mechanism in Differential Privacy
The Journal of Privacy and Confidentiality, 2019 The Laplace mechanism is the workhorse of differential privacy, applied to many instances where numerical data is processed. However, the Laplace mechanism can return semantically impossible values, such as negative counts, due to its infinite support ...
Naoise Holohan +3 more
doaj +1 more source
Learning and consistency [PDF]
, 1995 In designing learning algorithms it seems quite reasonable to construct them in such a way that all data the algorithm already has obtained are correctly and completely reflected in the hypothesis the algorithm outputs on these data. However, this approach may totally fail. It may lead to the unsolvability of the learning problem, or it may exclude any
Rolf Wiehagen, Thomas Zeugmann
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Investigation of Relation between Organizational Culture and Organizational Commitment in Libraries Personnel of University of Tehran: Based on Dennison’s Organizational Culture Model [PDF]
تحقیقات کتابداری و اطلاعرسانی دانشگاهی, 2011 Objective: The present study aim is to explain relationship between Dennison’s organizational culture and personnel organizational commitment. Methodology: This is a practical research whose data was collected through survey.
Mohammad Sadegh Ziaee +2 more
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Animal, 2010 Sensory traits, such as juiciness and tenderness, are known to be important to the consumer and thus will influence their consumption of meat, specifically beef.
J.L. Gill +5 more
doaj +1 more source