Results 191 to 200 of about 82,240 (227)

Update, translation, cross-cultural adaptation, and validation of Nottingham Stroke Dressing Assessment into Spanish. [PDF]

Sci Rep
de Blas-Zamorano P, Merchán-Baeza JA, Fernández-Solano AJ, Rodríguez-Bailón M, Szot AC, Ghaziani E, Walker M, Pérez-Cruzado D.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Metabolic Saliency as KL-Divergence Estimator: Information-Geometric Attribution of Systemic Stress in JSE Equity Network. [PDF]

Entropy (Basel)
Moroke ND.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Adolescent developmental task accomplishment: a descriptive analysis of Havighurst's framework among secondary-school students. [PDF]

Front Psychol
Ofem UJ, Anake PM, Anyin NN, Mpoun Obibessong V, Abuo CB, David Ahmed E, Amushe J, Esther-Wanibokom Otu P, Ukatu J.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CauseHSI: Counterfactual-Augmented Domain Generalization for Hyperspectral Image Classification via Causal Disentanglement. [PDF]

J Imaging
Li X, Yang Z, Li W.
europepmc   +1 more source

Functional Recovery and Emotional Burden After Burn Injury: A Quality of Life Assessment in Romanian Burn Survivors. [PDF]

Diseases
Ungureanu A, Marinescu MC, Trandafir AN, Coviltir V, Giuglea C, Marinescu SA.   +5 more
europepmc   +1 more source

Cognitive Impairment as a Putative Mechanism of Self-Management Failure in Chronic Obstructive Pulmonary Disease: A Conceptual Narrative Review. [PDF]

J Clin Med
Almulhem MM, Siraj RA.
europepmc   +1 more source