Results 101 to 110 of about 468,968 (301)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Spatial Pattern Consistency among Different Remote-Sensing Land Cover Datasets: A Case Study in Northern Laos

open access: yesISPRS International Journal of Geo-Information, 2019
Comparisons of the accuracy and consistency of different remote-sensing land cover datasets are important for the rational application of multi-source land cover datasets to regional development, or to studies of global or local environmental change ...
Junmei Kang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Consistency of personality traits and verbal behaviour in leaderless small group discussion [PDF]

open access: yes, 1990
The research was concerned with consistency between three types of trait interaction and verbal behaviour in small student discussion groups. Hypotheses based on trait interactions of varying saliency were tested against samples of verbal behaviour ...
Halpin, Nicholas Richard, Halpin, N.R
core  

PROGRAM SYSTEM FOR EXPERT KNOWLEDGE INPUT

open access: yesВестник Донского государственного технического университета, 2018
Functionability and structure of the expert system input unit for engineering and technological service of the complex machinery are considered. Program system interface is given.
Valery P. Dimitrov   +3 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

PROGRAM SYSTEM FOR EXPERT KNOWLEDGE INPUT

open access: yesAdvanced Engineering Research, 2011
Functionability and structure of the expert system input unit for engineering and technological service of the complex machinery are considered. Program system interface is given.
Valery P. Dimitrov   +3 more
doaj  

Multimodal Image Matching Based on Block Phase Consistency and Orientation Index Map

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Due to the differences in imaging mechanisms and nonlinear radiation distortion (NRD) between images of different modalities, multimodal image matching methods encounter challenges in matching performance. To address this issue, we propose a novel method
Fanghong Liu   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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