Results 31 to 40 of about 115,917 (266)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Research on the rebound rule of a pit bottom caused by excavation of typical strata

open access: yesFrontiers in Earth Science
In practical engineering, the magnitude of soil unloading rebound is closely related to the physical and mechanical properties of the soil. Therefore, there are significant differences in geological conditions among the different regions.
Qingyuan Yang   +6 more
doaj   +1 more source

On influencing factors of quick consolidated-drained triaxial tests of widely-graded gravelly soils

open access: yesRock and Soil Mechanics, 2021
Widely-graded gravelly soil is composed of gravelly and clayey material in a certain proportion. It has the characteristics of low compressibility and high shear strength.
CHEN Zhi-bo   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Anionic Effects on Flocculation and Consolidation of Sediments Contaminated by Heavy Metals

open access: yesApplied Sciences
The remediation of heavy metal-contaminated sediments is a significant environmental challenge. While cation effects are well studied, the influence of common co-existing anions on treatment efficiency remains poorly quantified. This study systematically
Wenjing Sun, Yijie Sun, Yitian Lu
doaj   +1 more source

Test methods for self-weight consolidation coefficient of deposited sediment

open access: yesYantu gongcheng xuebao, 2017
The consolidation coefficient in the Terzaghi theory is constant. It will cause significant errors if it is directly applied in the calculation of large strain consolidation of deposited sediment.
GUO Shuai-jie 1,2, ZHANG Fu-hai 3, SONG Xu-guo 1,2
doaj   +1 more source

A Comprehensive Review of Large Strain Consolidation Testing for Application in Oil Sands Mine Tailings

open access: yesMining, 2023
Oil sand tailings are a mixture of sand, fines, water, and a residual amount of un-extracted bitumen in varying proportions. Tailings management is highly dependent on the consolidation behavior of the tailings.
Mahmoud Ahmed   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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