Results 251 to 260 of about 238,913 (362)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A Quantitative and Qualitative Analysis of the Phonetic and Phonological Development of Children with Cochlear Implants and Its Relationship with Early Literacy. [PDF]

Audiol Res
Majorano M, Santangelo M, Redondi I, Barachetti C, Guerzoni L, Cuda D.   +5 more
europepmc   +1 more source

A Comparative Analysis of English and Lamaholot (Eastern Adonara Dialect) Consonants

Yohanes Octovianus L. Awololon, Ni Made Diana Erfiani, Ni Luh Desy Suari Dewi   +2 more
openalex   +2 more sources

Influences on articulatory timing in consonant sequences

, 1996
D. Byrd
semanticscholar   +1 more source

Effect of masker type on native and non-native consonant perception in noise.

Journal of the Acoustical Society of America, 2006
García Lecumberri, M. Cooke
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Delayed auditory feedback increases speech production variability in typically fluent adults but has the opposite effect in stuttering adults. [PDF]

Front Hum Neurosci
Daliri A, Honda S, Max L.
europepmc   +1 more source

Consonant-Vocaal relaties in (Broca-)Afasie: Een beschrijving van patiënt CH

, 2012
Marleen Kunneman, L.W. Boyce-van der Wal, A.C.M. Rietveld, Niels O. Schiller   +3 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source