Results 151 to 160 of about 925,080 (287)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Speech Characteristics of Childhood Apraxia of Speech in Hebrew-Speaking Children. [PDF]

Children (Basel)
Watter N, Maas E, Segal O.
europepmc   +1 more source

An unexpected gap in Gitksan consonant cluster phonotactics

, 2009
This short paper outlines the consonant cluster phonotactics of Giksan (Tsimshianic) by attempting a summary of the generalizations presented in Rigsby (1986).
Brown, Jason
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Consonance Shapes the Multisensory and Emotional Mappings of Musical Intervals Across English- and Mandarin-Speakers. [PDF]

Ann N Y Acad Sci
Di Stefano N, Ansani A, Schiavio A, Saarikallio S, Toiviainen P, Brattico E, Spence C.   +6 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Theta and Gamma Transcranial Alternating Current Stimulation (tACS) Modulate Mandarin Consonant and Lexical Tone Perception. [PDF]

Neurobiol Lang (Camb)
Wang Y, Yu K, Yin S, Liang B, Wang R.
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours. [PDF]

Cerebellum
Ahmed R, Boll-Avetisyan N, Grønbaek JK, Thomsen DB, Kingma A, Persson K, Mathiasen R, Dahl C, Carai A, Andreozzi B, Mastronuzzi A, Pizer B, Thorbinson C, Aquilina K, Hoving E, Juhler M, Jonkers R, de Aguiar V.   +17 more
europepmc   +1 more source