Results 41 to 50 of about 3,529 (273)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An instrumental study of consonant gemination

Journal of Phonetics, 1973
Abstract: An experiment is described aimed at investigating differences between single and geminate consonants in word-interior intervocalic position and at word boundaries. In addition the difference between short and long geminates, differences between the manifestations of geminates at word boundary in two languages and differences in production ...
Ilse Lehiste, Katherine Morton, M.A.A. Tatham   +2 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

A neglected phonetic law: The assimilation of pretonic yod to a following coronal in North-West Semitic [PDF]

, 2012
International audienceThis paper shows the existence of a pretonic assimilation of *y to a following coronal consonant (including *y from proto-Semitic *y and *w) in North-West Semitic languages.
Garnier, Romain, Jacques, Guillaume
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Geminates and Picard Pronominal Clitic Allomorphy

Catalan Journal of Linguistics, 2005
In this paper, we examine five pronominal clitics in Vimeu Picard with a geminate-consonant allomorph. Assuming a doubly-linked (non-moraic) representation of geminates, we attribute the four different patterns observed to four different underlying ...
Brian José, Julie Auger
doaj   +1 more source

Consonant gemination in Buginese

Bijdragen tot de taal-, land- en volkenkunde / Journal of the Humanities and Social Sciences of Southeast Asia, 1990
The articulation of consonant gemination in Buginese is to some extent different in continuants and in stops. Since the continuants s, r, /, ra, , and ng are produced with only partial or incomplete stricture of the articulatory cavities, their articulation, including the production of sound, can be continued for some time, and in gemination is ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

An analysis of phonetic and phonological systems in classical Arabic and English: a contrastive study

Cogent Education
This study conducts a contrastive analysis of the phonetic and phonological systems of Classical Arabic and English, drawing from empirical speech data of 25 native informants.
Abdiwali Ali Addow, Suleiman Ibrahim Omar, Ahmed Abdullahi Mohamud   +2 more
doaj   +1 more source