Results 71 to 80 of about 53,993 (275)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Vowel duration in stressed position in central & northern varieties of standard Italian [PDF]
, 2011 We report the results of a pilot study investigating the effect of 2 regional accents on stressed vowel duration according to word-position and syllable type in Central v. Northern accents of Standard Italian.
Hajek, John, Lee, Wai-Sum, Stevens, Mary
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Human Noun Pluralization in Northern Luzon Languages [PDF]
, 2006 It is a great pleasure for me to be able to offer this paper in honor of Professor Paul Jen-kuei Li, one of the most productive linguists working on the Austronesian languages of Taiwan. I have known Paul since his student days at the University of Hawai`
Reid, Lawrence A.
core
How pervasive is preaspiration? Investigating sonorant devoicing in Sienese Italian [PDF]
, 2004 We have recently found that voiceless geminates in Sienese Italian are frequently preaspirated, eg. /sette/ > [sehte] 'seven'. Within the few (mostly Scandinavian) languages that are reported to have preaspirated voiceless stops, a phonetically similar ...
Hajek, John, Stevens, Mary
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The phonology of Japanese /r/: a panchronic account [PDF]
, 2014 The aim of this study is to understand how /r/ emerged and developed in Proto-Japanese and how the conditions of its emergence shed light on its present phonological behavior.
Labrune, Laurence
core +1 more source