Results 71 to 80 of about 3,529 (273)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Blocking of word-boundary consonant lengthening in Sienese Italian [PDF]
, 2006 This paper examines an aspect of Raddoppiamento sintattico (RS), the lengthening of word-initial consonants following certain words e.g. tre [mm]ele ‘three apples’ in Italian. Most phonological accounts claim the phenomenon is predictable and obligatory (
Hajek, John +3 more
core +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Human Noun Pluralization in Northern Luzon Languages [PDF]
, 2006 It is a great pleasure for me to be able to offer this paper in honor of Professor Paul Jen-kuei Li, one of the most productive linguists working on the Austronesian languages of Taiwan. I have known Paul since his student days at the University of Hawai`
Reid, Lawrence A.
core
No initial empty CV in clusterless languages [PDF]
, 2006 From the inception of strict CV in Lowenstamm (1996) the question of how surface clusters are licensed in Government Phonology has been a contentious one.
Kula, NC
core +1 more source
On Characterizing Sanskrit Gemination [PDF]
, 2015 In Sanskrit, various intervocalic biconsonantal clusters are affected by gemination, which istypically summarized by phonetic treatises as follows. First, postvocalic consonants followedby another consonant is geminated as in sapta- `seven\u27 > sappta ...
Yasuko Suzuki, 鈴木 保子
core +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source