Results 71 to 80 of about 543,244 (313)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.

American Journal of Human Genetics, 1998
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families, each with at least four cases of breast cancer, collected by the Breast Cancer Linkage Consortium.
D. Ford, D. Easton, Michael R. Stratton, S. Narod, D. Goldgar, P. Devilee, D. Bishop, B. Weber, G. Lenoir, J. Chang-Claude, H. Sobol, M. Teare, J. Struewing, A. Arason, S. Scherneck, J. Peto, T. Rebbeck, P. Tonin, S. Neuhausen, R. Barkardottir, J. Eyfjord, H. Lynch, B. Ponder, S. Gayther, J. Birch, A. Lindblom, D. Stoppa-Lyonnet, Y. Bignon, Å. Borg, U. Hamann, N. Haites, Rodney J. Scott, C. Maugard, H. Vasen, S. Seitz, L. Cannon-Albright, A. Schofield, M. Zelada-Hedman   +37 more
semanticscholar   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Anaerobic removal of the brl direct blue dye in Upflow Anaerobic Sludge Blanket (UASB) with activated carbon

Revista Colombiana de Biotecnología, 2015
In this research the brl direct blue dye was used for anaerobic removal with a bacterial consortium of industrial effluents from Industrial Park Río Seco (IPRS), Arequipa, Peru; in an anaerobic reactor of UASB Upflow with activated carbon.
Christian Zavala-Rivera, Alex Paul Dueñas Gonza, Ronald Eleazar Huarachi Olivera, Ursulo Avelino Yapo Pari, Rodrigo Mendoza-Puertas, Ronny Lázaro-Puma, Edwin Bocardo-Delgado   +6 more
doaj   +1 more source

2016-2020 Consortium Agreement of the International Internet Preservation Consortium

, 2016
This document contains the consortium agreement of the International Internet Preservation Consortium.
International Internet Preservation Consortium
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

CYFC Consortium Connections, Spring 2008

, 2008
This archival publication may not reflect current scientific knowledge or recommendations. Current information available from the University of Minnesota Extension: https://www.extension.umn.edu.Children, Youth & Family Consortium. (2008).
Children, Youth & Family Consortium
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Standardized End Point Definitions for Coronary Intervention Trials: The Academic Research Consortium-2 Consensus Document

European Heart Journal, 2018
The Academic Research Consortium (ARC)-2 initiative revisited the clinical and angiographic end point definitions in coronary device trials, proposed in 2007, to make them more suitable for use in clinical trials that include increasingly complex lesion ...
H. Garcia-Garcia, E. Mcfadden, A. Farb, R. Mehran, G. Stone, J. Spertus, Y. Onuma, M. Morel, G. van Es, Bram D. Zuckerman, W. Fearon, D. Taggart, A. Kappetein, M. Krucoff, P. Vranckx, S. Windecker, D. Cutlip, P. Serruys   +17 more
semanticscholar   +2 more sources

Exploring the resilience and stability of a defined human gut microbiota consortium: An isothermal microcalorimetric study

MicrobiologyOpen
The gut microbiota significantly contributes to human health and well‐being. The aim of this study was to evaluate the stability and resilience of a consortium composed of three next‐generation probiotics (NGPs) candidates originally found in the human ...
Anna Kattel, Valter Aro, Petri‐Jaan Lahtvee, Jekaterina Kazantseva, Arvi Jõers, Ranno Nahku, Isma Belouah   +6 more
doaj   +1 more source