Results 41 to 50 of about 50,594 (263)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Surfaces of Constant Curvature in the Pseudo-Galilean Space

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2012
We develop the local theory of surfaces immersed in the pseudo-Galilean space, a special type of Cayley-Klein spaces. We define principal, Gaussian, and mean curvatures.
Željka Milin Šipuš, Blaženka Divjak
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Surfaces of Revolution with Constant Mean Curvature in Galilean 3-Space

open access: yesMathematics
Revolution surfaces with zero mean curvature in the Galilean 3-space have been extensively studied in the literature. However, revolution surfaces with non-zero constant mean curvature in this geometric setting have not yet been investigated in a ...
İsmet Gölgeleyen   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

p-Branes with $$AdS_{p+1}$$ AdSp+1 vacuum as models of $$R^2$$ R2 gravity

open access: yesEuropean Physical Journal C: Particles and Fields, 2019
Branes with constant mean curvature of their hyper-worldsheets of codimension 1 are treated as the Nambu-Goldstone fields of the broken Poincare symmetry.
A. A. Zheltukhin
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Mean curvature flow for generating discrete surfaces with piecewise constant mean curvatures

open access: yesComputer Aided Geometric Design, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kazuki Hayashi   +4 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Closed 3-dimensional hypersurfaces with constant mean curvature and constant scalar curvature

open access: yesDuke Mathematical Journal, 1990
The main geometrical result of the paper is that such a hypersurface with non-negative scalar curvature in a space form is isoparametric, i.e. lies in a family of parallel constant mean curvature hypersurfaces.
de Almeida, Sebastião C.   +1 more
openaire   +3 more sources

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