Results 81 to 90 of about 13,582,991 (332)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Design of an Orbital Infrastructure to Guarantee Continuous Communication to the Lunar South Pole Region

Aerospace
The lunar south pole has gained significant attention due to its unique scientific value and potential for supporting future human exploration. Its potential water ice reservoirs and favourable conditions for long-term habitation make it a strategic ...
Nicolò Trabacchin, Giacomo Colombatti
doaj   +1 more source

Comparative Assessment Of Different Constellation Geometries For Space-Based Application [PDF]

, 2017
As services from space are becoming an asset for life on Earth and the demand for data from space increases, the international interest in satellite constellations is increasingly growing.
Bernelli Zazzera, F., Colombo, C., Huang, S.   +2 more
core  

Downlink Precoding for Massive MIMO Systems Exploiting Virtual Channel Model Sparsity

, 2017
In this paper, the problem of designing a forward link linear precoder for Massive Multiple-Input Multiple-Output (MIMO) systems in conjunction with Quadrature Amplitude Modulation (QAM) is addressed.
Ayanoglu, Ender, Ketseoglou, Thomas
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Orbital Design Optimization for Large-Scale SAR Constellations: A Hybrid Framework Integrating Fuzzy Rules and Chaotic Sequences

Remote Sensing
Synthetic Aperture Radar (SAR) constellations have become a key technology for disaster monitoring, terrain mapping, and ocean surveillance due to their all-weather and high-resolution imaging capabilities.
Dacheng Liu, Yunkai Deng, Sheng Chang, Mengxia Zhu, Yusheng Zhang, Zixuan Zhang   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

New Design of Constellation and Bit Mapping for Dual Mode OFDM-IM

IEEE Access, 2019
Dual mode orthogonal frequency division multiplexing with index modulation (DM-OFDM-IM) is recently proposed, where the subcarriers within each subblock are divided into two groups, which are modulated by two distinguishable signal constellations.
Kee-Hoon Kim, Hosung Park
doaj   +1 more source