Results 71 to 80 of about 17,915 (258)

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Precedence permutation patterns creating criticality constellations: Exploring a conjecture on nonlinear activities with continuous links

open access: yesOrganization, Technology and Management in Construction: An International Journal, 2018
The inaugural challenge of the 2016 Creative Construction Conference has posed two related questions on how many possible criticality constellations with different behaviors for delays and acceleration exist and how said constellations can occur for ...
Lucko Gunnar, Su Yi
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Identification of Postclassic Maya Constellations from the Venus Pages of the Dresden Codex

open access: yesEstudios de Cultura Maya, 2010
Ancient Mayan civilization, flourished from 1200 B.C. to 1500 A.D., has left numerous hieroglyphic texts on astronomical observations and calendar. In particular, the Dresden Codex contains the most details of such ancient Mayan heritage.
Changbom Park, Heajoo Chung
doaj  

Cultural Constellations: Burckhardtsource.org

open access: yesOpen Library of Humanities, 2017
Burckhardtsource.org hosts a corpus of over 1,000 documents forming the correspondence of more than 300 different authors with Swiss historian of art and culture Jacob Burckhardt (1818–1897). Dr. Susanne Müller and Dr.
Costanza Giannaccini   +2 more
doaj   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Deployment of Constellation with Different Inclinations Using the Nodal Precession and Thrust

open access: yesSensors
Strategy selection is critical for constellation deployment missions, both in terms of energy consumption and time cost. The different effects of impulse thrust and continuous thrust on orbit elements lead to a different choice of strategy.
Shuailong Zhao   +3 more
doaj   +1 more source

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